TBC-2 is required for embryonic yolk protein storage and larval survival during L1 diapause in Caenorhabditis elegans

C. elegans first stage (L1) larvae hatched in the absence of food, arrest development and enter an L1 diapause, whereby they can survive starvation for several weeks. The physiological and metabolic requirements for survival during L1 diapause are poorly understood. However, yolk, a cholesterol bind...

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Veröffentlicht in:	PloS one 2010-12, Vol.5 (12), p.e15662-e15662
Hauptverfasser:	Chotard, Laëtitia, Skorobogata, Olga, Sylvain, Marc-André, Shrivastava, Sanhita, Rocheleau, Christian E
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amines - pharmacology Animals Biology Caenorhabditis elegans Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - physiology Cell cycle Cholesterol Cholesterol - metabolism Diapause Embryogenesis Embryonic growth stage Embryos Endocrinology Endosomes - metabolism Energy sources Fluorescence Food Fusion protein Gene Expression Regulation, Developmental Green fluorescent protein Green Fluorescent Proteins - metabolism GTPase-Activating Proteins - genetics GTPase-Activating Proteins - physiology Guanosine triphosphatases Kinases Larva - metabolism Larvae Lysosomes Lysosomes - metabolism Medicine Metabolism Models, Biological Morphogenesis Mutants Mutation Nematodes Phenotype Physiological aspects Protein Binding Protein transport Proteins Starvation Survival Worms Yolk Yolk protein
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