Low CD4/CD8 T-cell ratio associated with inflammatory arthropathy in human T-cell leukemia virus type I Tax transgenic mice

Human T-cell leukemia virus type I (HTLV-1) can cause an aggressive malignancy known as adult T-cell leukemia/lymphoma (ATL) as well as inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). A transgenic mouse that expresses HTLV-1 Tax also develops T-cell...

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Veröffentlicht in:	PloS one 2011-04, Vol.6 (4), p.e18518
Hauptverfasser:	Ohsugi, Takeo, Kumasaka, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Analysis Animal models Animals Antigens Arthritis Arthritis, Rheumatoid - chemically induced Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology Autoimmune diseases Biology CD25 antigen CD4 antigen CD5 Antigens - metabolism CD8 antigen CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - metabolism Cell Count Central nervous system diseases Chemokine receptors Collagen Collagen (type II) Collagen Type II - adverse effects Cytokines Diabetes Disease Female Forkhead Transcription Factors - metabolism Foxp3 protein Gene expression Gene Products, tax - genetics Genetic engineering Genomes Hereditary spastic paraplegia Human T-lymphotropic virus 1 Humans Immunization Immunoregulation Inflammation Inflammation - chemically induced Inflammation - genetics Inflammation - immunology Inflammation - pathology Inflammatory diseases Joint diseases Kinases Leukemia Light therapy Lymphocytes Lymphocytes T Lymphoma Male Malignancy Medicine Mice Mice, Transgenic mRNA Mutation Pathogenesis Patients Proteins Receptors, CCR4 - metabolism Rheumatoid arthritis Rheumatoid factor RNA Rodents Signal transduction Spastic paraparesis Spinal cord Spleen Spleen - cytology Spleen - immunology T cells T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - metabolism T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - metabolism Tax increases Transgenic animals Transgenic mice Tropical spastic paraparesis Viruses
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