Altered effective connectivity network of the amygdala in social anxiety disorder: a resting-state FMRI study
The amygdala is often found to be abnormally recruited in social anxiety disorder (SAD) patients. The question whether amygdala activation is primarily abnormal and affects other brain systems or whether it responds "normally" to an abnormal pattern of information conveyed by other brain s...
Gespeichert in:
| Veröffentlicht in: | PloS one 2010-12, Vol.5 (12), p.e15238-e15238 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e15238 |
|---|---|
| container_issue | 12 |
| container_start_page | e15238 |
| container_title | PloS one |
| container_volume | 5 |
| creator | Liao, Wei Qiu, Changjian Gentili, Claudio Walter, Martin Pan, Zhengyong Ding, Jurong Zhang, Wei Gong, Qiyong Chen, Huafu |
| description | The amygdala is often found to be abnormally recruited in social anxiety disorder (SAD) patients. The question whether amygdala activation is primarily abnormal and affects other brain systems or whether it responds "normally" to an abnormal pattern of information conveyed by other brain structures remained unanswered. To address this question, we investigated a network of effective connectivity associated with the amygdala using Granger causality analysis on resting-state functional MRI data of 22 SAD patients and 21 healthy controls (HC). Implications of abnormal effective connectivity and clinical severity were investigated using the Liebowitz Social Anxiety Scale (LSAS). Decreased influence from inferior temporal gyrus (ITG) to amygdala was found in SAD, while bidirectional influences between amygdala and visual cortices were increased compared to HCs. Clinical relevance of decreased effective connectivity from ITG to amygdala was suggested by a negative correlation of LSAS avoidance scores and the value of Granger causality. Our study is the first to reveal a network of abnormal effective connectivity of core structures in SAD. This is in support of a disregulation in predescribed modules involved in affect control. The amygdala is placed in a central position of dysfunction characterized both by decreased regulatory influence of orbitofrontal cortex and increased crosstalk with visual cortex. The model which is proposed based on our results lends neurobiological support towards cognitive models considering disinhibition and an attentional bias towards negative stimuli as a core feature of the disorder. |
| doi_str_mv | 10.1371/journal.pone.0015238 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1296286238</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A473813456</galeid><doaj_id>oai_doaj_org_article_453f3397612d43e7a801d808ffc69756</doaj_id><sourcerecordid>A473813456</sourcerecordid><originalsourceid>FETCH-LOGICAL-c757t-74f3ab95aa03a3f6a24f261d59ec9b3843df501c2bb50f6af621c0a37ae076083</originalsourceid><addsrcrecordid>eNqNk11rFDEUhgdRbK3-A9GAoHixaz4mmRkvhFKsLlQK9eM2nM2c7KbOJm2Sqd1_b9puS1d6IblIOHnOe5I3OVX1ktEpEw37cBrG6GGYngWPU0qZ5KJ9VO2yTvCJ4lQ8vrfeqZ6ldEqpFK1ST6sdzkpQSrZbrfaHjBF7gtaiye4CiQneXy9dXhOP-U-Iv0mwJC-RwGq96GEA4jxJwTgYCPhLh4XsXQqxx_iRAImYsvOLScqQkRx-O5mRlMd-_bx6YmFI-GIz71U_Dz__OPg6OTr-MjvYP5qYRjZ50tRWwLyTAFSAsAp4bblivezQdHPR1qK3kjLD53NJy7ZVnBkKogGkjaKt2Kte3-ieDSHpjVNJM94p3qpiVCFmN0Qf4FSfRbeCuNYBnL4OhLjQELMzA-paCitE1yjG-1pgAy1lfUtba43qGqmK1qdNtXG-wt6gzxGGLdHtHe-WehEutKC0VU1XBN5tBGI4H4t3euWSwWEAj2FMuuVcyoYpVsg3_5APX25DLaCc33kbSllzpan360a0TNTXx54-QJXR48qVT4DWlfhWwvuthMJkvMwLGFPSs-8n_88e_9pm395jlwhDXqYwjNkFn7bB-gY0MaQU0d55zKi-aopbN_RVU-hNU5S0V_ff5y7ptgvEX2k4Bus</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1296286238</pqid></control><display><type>article</type><title>Altered effective connectivity network of the amygdala in social anxiety disorder: a resting-state FMRI study</title><source>PLoS</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>EZB Electronic Journals Library</source><creator>Liao, Wei ; Qiu, Changjian ; Gentili, Claudio ; Walter, Martin ; Pan, Zhengyong ; Ding, Jurong ; Zhang, Wei ; Gong, Qiyong ; Chen, Huafu</creator><creatorcontrib>Liao, Wei ; Qiu, Changjian ; Gentili, Claudio ; Walter, Martin ; Pan, Zhengyong ; Ding, Jurong ; Zhang, Wei ; Gong, Qiyong ; Chen, Huafu</creatorcontrib><description>The amygdala is often found to be abnormally recruited in social anxiety disorder (SAD) patients. The question whether amygdala activation is primarily abnormal and affects other brain systems or whether it responds "normally" to an abnormal pattern of information conveyed by other brain structures remained unanswered. To address this question, we investigated a network of effective connectivity associated with the amygdala using Granger causality analysis on resting-state functional MRI data of 22 SAD patients and 21 healthy controls (HC). Implications of abnormal effective connectivity and clinical severity were investigated using the Liebowitz Social Anxiety Scale (LSAS). Decreased influence from inferior temporal gyrus (ITG) to amygdala was found in SAD, while bidirectional influences between amygdala and visual cortices were increased compared to HCs. Clinical relevance of decreased effective connectivity from ITG to amygdala was suggested by a negative correlation of LSAS avoidance scores and the value of Granger causality. Our study is the first to reveal a network of abnormal effective connectivity of core structures in SAD. This is in support of a disregulation in predescribed modules involved in affect control. The amygdala is placed in a central position of dysfunction characterized both by decreased regulatory influence of orbitofrontal cortex and increased crosstalk with visual cortex. The model which is proposed based on our results lends neurobiological support towards cognitive models considering disinhibition and an attentional bias towards negative stimuli as a core feature of the disorder.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0015238</identifier><identifier>PMID: 21203551</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Adults ; Amygdala ; Amygdala - pathology ; Anxiety ; Anxiety Disorders - physiopathology ; Attention ; Attentional bias ; Autism ; Brain ; Brain mapping ; Brain Mapping - methods ; Case-Control Studies ; Child development ; Cognition ; Cognitive ability ; Cortex (temporal) ; Crosstalk ; Education ; Emotions ; Fear & phobias ; Female ; Functional magnetic resonance imaging ; Humans ; Identification ; Information processing ; Laboratories ; Life sciences ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Mediation ; Medical imaging ; Medicine ; Mental health ; Models, Statistical ; Neural networks ; Neurosciences ; NMR ; Nuclear magnetic resonance ; Patients ; Psychiatry ; Public speaking ; Regression Analysis ; Social phobia ; Studies ; Temporal gyrus ; Temporal Lobe - pathology ; Visual cortex</subject><ispartof>PloS one, 2010-12, Vol.5 (12), p.e15238-e15238</ispartof><rights>COPYRIGHT 2010 Public Library of Science</rights><rights>2010 Liao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Liao et al. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c757t-74f3ab95aa03a3f6a24f261d59ec9b3843df501c2bb50f6af621c0a37ae076083</citedby><cites>FETCH-LOGICAL-c757t-74f3ab95aa03a3f6a24f261d59ec9b3843df501c2bb50f6af621c0a37ae076083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008679/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008679/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21203551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liao, Wei</creatorcontrib><creatorcontrib>Qiu, Changjian</creatorcontrib><creatorcontrib>Gentili, Claudio</creatorcontrib><creatorcontrib>Walter, Martin</creatorcontrib><creatorcontrib>Pan, Zhengyong</creatorcontrib><creatorcontrib>Ding, Jurong</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><creatorcontrib>Gong, Qiyong</creatorcontrib><creatorcontrib>Chen, Huafu</creatorcontrib><title>Altered effective connectivity network of the amygdala in social anxiety disorder: a resting-state FMRI study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The amygdala is often found to be abnormally recruited in social anxiety disorder (SAD) patients. The question whether amygdala activation is primarily abnormal and affects other brain systems or whether it responds "normally" to an abnormal pattern of information conveyed by other brain structures remained unanswered. To address this question, we investigated a network of effective connectivity associated with the amygdala using Granger causality analysis on resting-state functional MRI data of 22 SAD patients and 21 healthy controls (HC). Implications of abnormal effective connectivity and clinical severity were investigated using the Liebowitz Social Anxiety Scale (LSAS). Decreased influence from inferior temporal gyrus (ITG) to amygdala was found in SAD, while bidirectional influences between amygdala and visual cortices were increased compared to HCs. Clinical relevance of decreased effective connectivity from ITG to amygdala was suggested by a negative correlation of LSAS avoidance scores and the value of Granger causality. Our study is the first to reveal a network of abnormal effective connectivity of core structures in SAD. This is in support of a disregulation in predescribed modules involved in affect control. The amygdala is placed in a central position of dysfunction characterized both by decreased regulatory influence of orbitofrontal cortex and increased crosstalk with visual cortex. The model which is proposed based on our results lends neurobiological support towards cognitive models considering disinhibition and an attentional bias towards negative stimuli as a core feature of the disorder.</description><subject>Adult</subject><subject>Adults</subject><subject>Amygdala</subject><subject>Amygdala - pathology</subject><subject>Anxiety</subject><subject>Anxiety Disorders - physiopathology</subject><subject>Attention</subject><subject>Attentional bias</subject><subject>Autism</subject><subject>Brain</subject><subject>Brain mapping</subject><subject>Brain Mapping - methods</subject><subject>Case-Control Studies</subject><subject>Child development</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Cortex (temporal)</subject><subject>Crosstalk</subject><subject>Education</subject><subject>Emotions</subject><subject>Fear & phobias</subject><subject>Female</subject><subject>Functional magnetic resonance imaging</subject><subject>Humans</subject><subject>Identification</subject><subject>Information processing</subject><subject>Laboratories</subject><subject>Life sciences</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Mediation</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Mental health</subject><subject>Models, Statistical</subject><subject>Neural networks</subject><subject>Neurosciences</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Patients</subject><subject>Psychiatry</subject><subject>Public speaking</subject><subject>Regression Analysis</subject><subject>Social phobia</subject><subject>Studies</subject><subject>Temporal gyrus</subject><subject>Temporal Lobe - pathology</subject><subject>Visual cortex</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11rFDEUhgdRbK3-A9GAoHixaz4mmRkvhFKsLlQK9eM2nM2c7KbOJm2Sqd1_b9puS1d6IblIOHnOe5I3OVX1ktEpEw37cBrG6GGYngWPU0qZ5KJ9VO2yTvCJ4lQ8vrfeqZ6ldEqpFK1ST6sdzkpQSrZbrfaHjBF7gtaiye4CiQneXy9dXhOP-U-Iv0mwJC-RwGq96GEA4jxJwTgYCPhLh4XsXQqxx_iRAImYsvOLScqQkRx-O5mRlMd-_bx6YmFI-GIz71U_Dz__OPg6OTr-MjvYP5qYRjZ50tRWwLyTAFSAsAp4bblivezQdHPR1qK3kjLD53NJy7ZVnBkKogGkjaKt2Kte3-ieDSHpjVNJM94p3qpiVCFmN0Qf4FSfRbeCuNYBnL4OhLjQELMzA-paCitE1yjG-1pgAy1lfUtba43qGqmK1qdNtXG-wt6gzxGGLdHtHe-WehEutKC0VU1XBN5tBGI4H4t3euWSwWEAj2FMuuVcyoYpVsg3_5APX25DLaCc33kbSllzpan360a0TNTXx54-QJXR48qVT4DWlfhWwvuthMJkvMwLGFPSs-8n_88e_9pm395jlwhDXqYwjNkFn7bB-gY0MaQU0d55zKi-aopbN_RVU-hNU5S0V_ff5y7ptgvEX2k4Bus</recordid><startdate>20101222</startdate><enddate>20101222</enddate><creator>Liao, Wei</creator><creator>Qiu, Changjian</creator><creator>Gentili, Claudio</creator><creator>Walter, Martin</creator><creator>Pan, Zhengyong</creator><creator>Ding, Jurong</creator><creator>Zhang, Wei</creator><creator>Gong, Qiyong</creator><creator>Chen, Huafu</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20101222</creationdate><title>Altered effective connectivity network of the amygdala in social anxiety disorder: a resting-state FMRI study</title><author>Liao, Wei ; Qiu, Changjian ; Gentili, Claudio ; Walter, Martin ; Pan, Zhengyong ; Ding, Jurong ; Zhang, Wei ; Gong, Qiyong ; Chen, Huafu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c757t-74f3ab95aa03a3f6a24f261d59ec9b3843df501c2bb50f6af621c0a37ae076083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Amygdala</topic><topic>Amygdala - pathology</topic><topic>Anxiety</topic><topic>Anxiety Disorders - physiopathology</topic><topic>Attention</topic><topic>Attentional bias</topic><topic>Autism</topic><topic>Brain</topic><topic>Brain mapping</topic><topic>Brain Mapping - methods</topic><topic>Case-Control Studies</topic><topic>Child development</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Cortex (temporal)</topic><topic>Crosstalk</topic><topic>Education</topic><topic>Emotions</topic><topic>Fear & phobias</topic><topic>Female</topic><topic>Functional magnetic resonance imaging</topic><topic>Humans</topic><topic>Identification</topic><topic>Information processing</topic><topic>Laboratories</topic><topic>Life sciences</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Mediation</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Mental health</topic><topic>Models, Statistical</topic><topic>Neural networks</topic><topic>Neurosciences</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Patients</topic><topic>Psychiatry</topic><topic>Public speaking</topic><topic>Regression Analysis</topic><topic>Social phobia</topic><topic>Studies</topic><topic>Temporal gyrus</topic><topic>Temporal Lobe - pathology</topic><topic>Visual cortex</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liao, Wei</creatorcontrib><creatorcontrib>Qiu, Changjian</creatorcontrib><creatorcontrib>Gentili, Claudio</creatorcontrib><creatorcontrib>Walter, Martin</creatorcontrib><creatorcontrib>Pan, Zhengyong</creatorcontrib><creatorcontrib>Ding, Jurong</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><creatorcontrib>Gong, Qiyong</creatorcontrib><creatorcontrib>Chen, Huafu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale_Opposing Viewpoints In Context</collection><collection>Gale in Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database (ProQuest)</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Complete (ProQuest Database)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Database (Proquest)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liao, Wei</au><au>Qiu, Changjian</au><au>Gentili, Claudio</au><au>Walter, Martin</au><au>Pan, Zhengyong</au><au>Ding, Jurong</au><au>Zhang, Wei</au><au>Gong, Qiyong</au><au>Chen, Huafu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered effective connectivity network of the amygdala in social anxiety disorder: a resting-state FMRI study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2010-12-22</date><risdate>2010</risdate><volume>5</volume><issue>12</issue><spage>e15238</spage><epage>e15238</epage><pages>e15238-e15238</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The amygdala is often found to be abnormally recruited in social anxiety disorder (SAD) patients. The question whether amygdala activation is primarily abnormal and affects other brain systems or whether it responds "normally" to an abnormal pattern of information conveyed by other brain structures remained unanswered. To address this question, we investigated a network of effective connectivity associated with the amygdala using Granger causality analysis on resting-state functional MRI data of 22 SAD patients and 21 healthy controls (HC). Implications of abnormal effective connectivity and clinical severity were investigated using the Liebowitz Social Anxiety Scale (LSAS). Decreased influence from inferior temporal gyrus (ITG) to amygdala was found in SAD, while bidirectional influences between amygdala and visual cortices were increased compared to HCs. Clinical relevance of decreased effective connectivity from ITG to amygdala was suggested by a negative correlation of LSAS avoidance scores and the value of Granger causality. Our study is the first to reveal a network of abnormal effective connectivity of core structures in SAD. This is in support of a disregulation in predescribed modules involved in affect control. The amygdala is placed in a central position of dysfunction characterized both by decreased regulatory influence of orbitofrontal cortex and increased crosstalk with visual cortex. The model which is proposed based on our results lends neurobiological support towards cognitive models considering disinhibition and an attentional bias towards negative stimuli as a core feature of the disorder.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21203551</pmid><doi>10.1371/journal.pone.0015238</doi><tpages>e15238</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2010-12, Vol.5 (12), p.e15238-e15238 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1296286238 |
| source | PLoS; MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Adult Adults Amygdala Amygdala - pathology Anxiety Anxiety Disorders - physiopathology Attention Attentional bias Autism Brain Brain mapping Brain Mapping - methods Case-Control Studies Child development Cognition Cognitive ability Cortex (temporal) Crosstalk Education Emotions Fear & phobias Female Functional magnetic resonance imaging Humans Identification Information processing Laboratories Life sciences Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Mediation Medical imaging Medicine Mental health Models, Statistical Neural networks Neurosciences NMR Nuclear magnetic resonance Patients Psychiatry Public speaking Regression Analysis Social phobia Studies Temporal gyrus Temporal Lobe - pathology Visual cortex |
| title | Altered effective connectivity network of the amygdala in social anxiety disorder: a resting-state FMRI study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T08%3A48%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Altered%20effective%20connectivity%20network%20of%20the%20amygdala%20in%20social%20anxiety%20disorder:%20a%20resting-state%20FMRI%20study&rft.jtitle=PloS%20one&rft.au=Liao,%20Wei&rft.date=2010-12-22&rft.volume=5&rft.issue=12&rft.spage=e15238&rft.epage=e15238&rft.pages=e15238-e15238&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0015238&rft_dat=%3Cgale_plos_%3EA473813456%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1296286238&rft_id=info:pmid/21203551&rft_galeid=A473813456&rft_doaj_id=oai_doaj_org_article_453f3397612d43e7a801d808ffc69756&rfr_iscdi=true |