Bone marrow support of the heart in pressure overload is lost with aging

Exogenous stem cell delivery is under investigation to prevent and treat cardiac dysfunction. It is less studied as to the extent endogenous bone marrow derived stem cells contribute to cardiac homeostais in response to stress and the affects of aging on this stress response. To determine the role o...

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Veröffentlicht in:	PloS one 2010-12, Vol.5 (12), p.e15187-e15187
Hauptverfasser:	Sopko, Nikolai A, Turturice, Benjamin A, Becker, Mitchell E, Brown, Chase R, Dong, Feng, Popović, Zoran B, Penn, Marc S
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Animals Aorta Aorta - pathology Apoptosis Atherosclerosis Autophagy Biology Biomechanics Bone marrow Bone Marrow - physiology Bone Marrow Cells - cytology Bone Marrow Transplantation Cell adhesion & migration Cell cycle Cell migration Cell Movement Cell Proliferation Cellular stress response Cytokines Echocardiography - methods Fibrosis Heart Heart - physiology Heart attacks Heart diseases Heart failure Homeostasis Hypertrophy Laboratories Male Medical research Medicine Mice Mice, Inbred C57BL Muscle Cells - cytology Myocytes, Cardiac - cytology Pressure Residential density Signal transduction Stem cell transplantation Stem cells Stem Cells - cytology Transplantation
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