Syntaxin 5 is required for copper homeostasis in Drosophila and mammals

Copper is essential for aerobic life, but many aspects of its cellular uptake and distribution remain to be fully elucidated. A genome-wide screen for copper homeostasis genes in Drosophila melanogaster identified the SNARE gene Syntaxin 5 (Syx5) as playing an important role in copper regulation; fl...

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Veröffentlicht in:	PloS one 2010-12, Vol.5 (12), p.e14303-e14303
Hauptverfasser:	Norgate, Melanie, Southon, Adam, Greenough, Mark, Cater, Michael, Farlow, Ashley, Batterham, Philip, Bush, Ashley I, Subramaniam, V Nathan, Burke, Richard, Camakaris, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Alzheimers disease Animals Animals, Genetically Modified Biology Cation Transport Proteins - genetics Cation Transport Proteins - metabolism Cell Biology Cell division Cell lines Cell Membrane - metabolism Cells (Biology) Copper Copper - metabolism Defects Diet Drosophila Drosophila melanogaster Drosophila melanogaster - genetics Drosophila Proteins - genetics Drosophila Proteins - metabolism Enzymes Fibroblasts Gene expression Genetic aspects Genetics Genetics and Genomics/Disease Models Genetics and Genomics/Gene Function Genomes Heterozygote Homeostasis Humans Inorganic chemistry Insects Lethality Mammals Medical research Mental health Metabolism Mutation Neurons - metabolism Pathogenesis Phenotype Phenotypes Plasma Proteins Qa-SNARE Proteins - genetics Qa-SNARE Proteins - metabolism RNA Interference SNAP receptors Syntaxin Transporter Trends
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