The PTEN phosphatase controls intestinal epithelial cell polarity and barrier function: role in colorectal cancer progression

The PTEN phosphatase acts on phosphatidylinositol 3,4,5-triphosphates resulting from phosphatidylinositol 3-kinase (PI3K) activation. PTEN expression has been shown to be decreased in colorectal cancer. Little is known however as to the specific cellular role of PTEN in human intestinal epithelial c...

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Veröffentlicht in:	PloS one 2010-12, Vol.5 (12), p.e15742-e15742
Hauptverfasser:	Langlois, Marie-Josée, Bergeron, Sébastien, Bernatchez, Gérald, Boudreau, François, Saucier, Caroline, Perreault, Nathalie, Carrier, Julie C, Rivard, Nathalie
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Analysis Animals Biology Caco-2 Cells Cancer Cancer metastasis Cell adhesion Cell adhesion & migration Cell differentiation Cell junctions Cell Line, Tumor Cell migration Cell Polarity Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - enzymology Differentiation Electron microscopy Epithelial cells Epithelial Cells - cytology Female Gastroenterology Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Health aspects Homeostasis Humans Immunoglobulins Intestine Intestines - enzymology Kinases Medical research Medicine Metastases Metastasis Mice Mice, Nude Mice, SCID Mutation Permeability Phosphatase Phosphatases Polarity Polarization Prostate cancer Proteins PTEN Phosphohydrolase - metabolism PTEN protein Tumorigenesis Tumors Wounds
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