Thrombin induces macrophage migration inhibitory factor release and upregulation in urothelium: a possible contribution to bladder inflammation

Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine expressed by urothelial cells that mediates bladder inflammation. We investigated the effect of stimulation with thrombin, a Protease Activated Receptor-1 (PAR1) agonist, on MIF release and MIF mRNA upregulation in urothelia...

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Veröffentlicht in:	PloS one 2010-12, Vol.5 (12), p.e15904
Hauptverfasser:	Vera, Pedro L, Wolfe, Terra E, Braley, Alexander E, Meyer-Siegler, Katherine L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biology Bladder Cell culture Cell Line Culture media Cytokines Cytokines - metabolism Data analysis Dose-Response Relationship, Drug Enzyme-linked immunosorbent assay Gene expression Humans Immunoglobulins Inflammation Leukocyte migration Lidocaine Macrophage migration inhibitory factor Macrophage Migration-Inhibitory Factors - metabolism Macrophages Male Medicine Molecular weight mRNA Neutrophils Pentobarbital Polymerase chain reaction Prostate Proteinase-activated receptor 1 R&D Rats Real time Receptor, PAR-1 - metabolism Receptors Research & development Reverse Transcriptase Polymerase Chain Reaction RNA Signal transduction Stimulation Thrombin Thrombin - metabolism Tumor necrosis factor-TNF Up-Regulation Urinary bladder Urinary Bladder - metabolism Urinary Bladder - pathology Urine Urothelium Urothelium - metabolism Western blotting
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