The role of neutrophils during mild and severe influenza virus infections of mice

Neutrophils have been implicated in both protective and pathological responses following influenza virus infections. We have used mAb 1A8 (anti-Ly6G) to specifically deplete LyG6(high) neutrophils and induce neutropenia in mice infected with virus strains known to differ in virulence. Mice were also...

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Veröffentlicht in:	PloS one 2011-03, Vol.6 (3), p.e17618-e17618
Hauptverfasser:	Tate, Michelle D, Ioannidis, Lisa J, Croker, Ben, Brown, Lorena E, Brooks, Andrew G, Reading, Patrick C
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Antibodies, Monoclonal - pharmacology Avian flu Biology Bone marrow Disease control Granulocytes Health aspects Immunology Infections Influenza Influenza virus Influenza viruses Lectins Leukocytes Leukocytes (neutrophilic) Lungs Medical treatment Medicine Mice Mice, Inbred C57BL Neutropenia Neutrophil Infiltration - drug effects Neutrophils Neutrophils - drug effects Neutrophils - immunology Neutrophils - virology Orthomyxoviridae - drug effects Orthomyxoviridae - pathogenicity Orthomyxoviridae - physiology Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - prevention & control Orthomyxoviridae Infections - virology Pandemics Proteins Reading Replication Respiratory System - drug effects Respiratory System - immunology Respiratory System - virology Rodents Strains (organisms) Surfactants Swine flu Vaccines Virulence Virulence (Microbiology) Virulence - drug effects Virus Replication - drug effects Viruses
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