A single base-pair change in 2009 H1N1 hemagglutinin increases human receptor affinity and leads to efficient airborne viral transmission in ferrets

The 2009 H1N1 influenza A virus continues to circulate among the human population as the predominant H1N1 subtype. Epidemiological studies and airborne transmission studies using the ferret model have shown that the transmission efficiency of 2009 H1N1 viruses is lower than that of previous seasonal...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2011-03, Vol.6 (3), p.e17616
Hauptverfasser:	Jayaraman, Akila, Pappas, Claudia, Raman, Rahul, Belser, Jessica A, Viswanathan, Karthik, Shriver, Zachary, Tumpey, Terrence M, Sasisekharan, Ram
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Amino Acid Substitution - genetics Amino acids Analysis Animals Base Pairing - genetics Binding sites Biology Engineering Epidemics Epidemiology Ferrets - virology Gene mutation Genetics Glycan Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinins Human populations Humans Influenza Influenza A Influenza A virus Influenza A Virus, H1N1 Subtype - genetics Influenza A Virus, H1N1 Subtype - physiology Influenza, Human - virology Lectins Models, Molecular Mustela Mutant Proteins - metabolism Mutation Orthomyxoviridae Infections - transmission Orthomyxoviridae Infections - virology Pandemics Point mutation Protein Binding Receptors Receptors, Virus - metabolism Swine influenza Trachea - metabolism Transmission efficiency Vaccines Virus Replication Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!