Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice

The pathogenic road map leading to Alzheimer's disease (AD) is still not completely understood; however, a large body of studies in the last few years supports the idea that beside the classic hallmarks of the disease, namely the accumulation of amyloid-β (Aβ) and neurofibrillary tangles, other...

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Veröffentlicht in:	PloS one 2011-03, Vol.6 (3), p.e17971-e17971
Hauptverfasser:	Corona, Carlo, Frazzini, Valerio, Silvestri, Elena, Lattanzio, Rossano, La Sorda, Rossana, Piantelli, Mauro, Canzoniero, Lorella M T, Ciavardelli, Domenico, Rizzarelli, Enrico, Sensi, Stefano L
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Advertising executives Aging Aging - drug effects Aging - pathology Alzheimer Disease - complications Alzheimer Disease - drug therapy Alzheimer Disease - pathology Alzheimer's disease Alzheimers disease Amyloid Amyloid - metabolism Amyloid beta-Peptides - metabolism Animal cognition Animal models Animals Cadmium Carnosine Carnosine - pharmacology Carnosine - therapeutic use Chelating Agents - pharmacology Chelation Cognition Disorders - complications Cognition Disorders - drug therapy Cognitive ability Copper Data processing Diet Dietary Supplements Environmental science Enzymes Heat shock proteins Heavy metals Hippocampus Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Intracellular Space - drug effects Intracellular Space - metabolism Iron Medicine Memory Memory Disorders - complications Memory Disorders - drug therapy Mice Mice, Transgenic Mitochondria Mitochondria - drug effects Mitochondria - pathology Neurodegenerative diseases Neurofibrillary tangles Neurology Neurons - drug effects Neurons - metabolism Neurons - pathology Neurosciences Oncology Oxidative stress Pathology Phosphorylation Redox properties Rodents Supplementation Tau protein tau Proteins - metabolism Transgenic animals Zinc Zinc - metabolism
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