Plant-made trastuzumab (herceptin) inhibits HER2/Neu+ cell proliferation and retards tumor growth

Plant biotechnology provides a valuable contribution to global health, in part because it can decrease the cost of pharmaceutical products. Breast cancer can now be successfully treated by a humanized monoclonal antibody (mAb), trastuzumab (Herceptin). A course of treatment, however, is expensive an...

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Veröffentlicht in:	PloS one 2011-03, Vol.6 (3), p.e17541-e17541
Hauptverfasser:	Komarova, Tatiana V, Kosorukov, Vyacheslav S, Frolova, Olga Y, Petrunia, Igor V, Skrypnik, Ksenia A, Gleba, Yuri Y, Dorokhov, Yuri L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Animals Antibodies, Monoclonal - isolation & purification Antibodies, Monoclonal - metabolism Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Binding sites Biochemistry Biological products Biology Biotechnology Breast cancer Cancer Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cloning Cytotoxicity Epidermal growth factor Epitopes - immunology ErbB-2 protein Female Flow cytometry Fluorescence Gene expression Genes Genetic vectors Global health Growth Humans Immunoglobulins Immunotherapy In vivo methods and tests Kinases Light Light chains Mammals Mammary gland Medical research Medicine Metastasis Mice Molecular weight Monoclonal antibodies Neoplasms - drug therapy Neoplasms - pathology Nicotiana - metabolism Nicotiana benthamiana Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - pathology Peptides Peptides - immunology Phosphorylation Plant cells Plant extracts Plant Leaves - drug effects Plant Leaves - metabolism Plant tissues Plant viruses Plants (botany) Potatoes Protein Binding - drug effects Proteins Receptor, ErbB-2 - metabolism Science Targeted cancer therapy Tobacco Trastuzumab Tumors Vectors (Biology) Viruses Xenograft Model Antitumor Assays Xenografts
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