Homocysteine and familial longevity: the Leiden Longevity Study

Homocysteine concentrations are a read-out of methionine metabolism and have been related to changes in lifespan in animal models. In humans, high homocysteine concentrations are an important predictor of age related disease. We aimed to explore the association of homocysteine with familial longevit...

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Veröffentlicht in:	PloS one 2011-03, Vol.6 (3), p.e17543-e17543
Hauptverfasser:	Wijsman, Carolien A, van Heemst, Diana, Rozing, Maarten P, Slagboom, P Eline, Beekman, Marian, de Craen, Anton J M, Maier, Andrea B, Westendorp, Rudi G J, Blom, Henk J, Mooijaart, Simon P
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged, 80 and over Aging Alzheimer's disease Alzheimers disease Analysis Animal models Architects Biology Caenorhabditis elegans Cardiovascular disease Comorbidity Coronary vessels Creatinine Diabetes Enrichment Epidemiology Family Family medical history Female Folic acid Geriatrics Gerontology Growth hormones Health risk assessment Homocysteine Homocysteine - blood Humans Hypertension Immunoassay Life span Lipid peroxidation Longevity Longevity - physiology Male Medical statistics Medicine Metabolism Methionine Middle age Middle Aged Mortality Nematodes Netherlands Nonagenarian Offspring Oxidative stress Population Siblings Social and Behavioral Sciences Target marketing Thyroid gland Vitamin B
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