Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome
Our understanding of the basis of severe disease in malaria is incomplete. It is clear that pathology is in part related to the pro-inflammatory nature of the host response but a number of other factors are also thought to be involved, including the interaction between infected erythrocytes and endo...
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| creator | Ochola, Lucy B Siddondo, Bethsheba R Ocholla, Harold Nkya, Siana Kimani, Eva N Williams, Thomas N Makale, Johnstone O Liljander, Anne Urban, Britta C Bull, Pete C Szestak, Tadge Marsh, Kevin Craig, Alister G |
| description | Our understanding of the basis of severe disease in malaria is incomplete. It is clear that pathology is in part related to the pro-inflammatory nature of the host response but a number of other factors are also thought to be involved, including the interaction between infected erythrocytes and endothelium. This is a complex system involving several host receptors and a major parasite-derived variant antigen (PfEMP1) expressed on the surface of the infected erythrocyte membrane. Previous studies have suggested a role for ICAM-1 in the pathology of cerebral malaria, although these have been inconclusive. In this study we have examined the cytoadherence patterns of 101 patient isolates from varying clinical syndromes to CD36 and ICAM-1, and have used variant ICAM-1 proteins to further characterise this adhesive phenotype. Our results show that increased binding to CD36 is associated with uncomplicated malaria while ICAM-1 adhesion is raised in parasites from cerebral malaria cases. |
| doi_str_mv | 10.1371/journal.pone.0014741 |
| format | Article |
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It is clear that pathology is in part related to the pro-inflammatory nature of the host response but a number of other factors are also thought to be involved, including the interaction between infected erythrocytes and endothelium. This is a complex system involving several host receptors and a major parasite-derived variant antigen (PfEMP1) expressed on the surface of the infected erythrocyte membrane. Previous studies have suggested a role for ICAM-1 in the pathology of cerebral malaria, although these have been inconclusive. In this study we have examined the cytoadherence patterns of 101 patient isolates from varying clinical syndromes to CD36 and ICAM-1, and have used variant ICAM-1 proteins to further characterise this adhesive phenotype. Our results show that increased binding to CD36 is associated with uncomplicated malaria while ICAM-1 adhesion is raised in parasites from cerebral malaria cases.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0014741</identifier><identifier>PMID: 21390226</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Anemia ; Antigens ; CD36 antigen ; CD36 Antigens - metabolism ; Cell Adhesion - genetics ; Child ; Child, Preschool ; Clinical medicine ; Endothelium ; Erythrocytes ; Gene expression ; Genotype ; Host-Parasite Interactions ; Humans ; Infant ; Infections ; Infectious Diseases/Protozoal Infections ; Inflammation ; Intercellular adhesion molecule 1 ; Intercellular Adhesion Molecule-1 - metabolism ; Laboratories ; Ligands ; Malaria ; Malaria, Falciparum - parasitology ; Malaria, Falciparum - pathology ; Medical research ; Medicine ; Microbiology/Immunity to Infections ; Mutation ; Parasites ; Parasitology ; Pathology ; Plasmodium falciparum ; Plasmodium falciparum - cytology ; Plasmodium falciparum - genetics ; Plasmodium falciparum - isolation & purification ; Proteins ; Public Health and Epidemiology/Infectious Diseases ; Receptors ; Studies ; Tumor necrosis factor-TNF ; Vector-borne diseases</subject><ispartof>PloS one, 2011-03, Vol.6 (3), p.e14741</ispartof><rights>COPYRIGHT 2011 Public Library of Science</rights><rights>2011 Ochola et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2011-03, Vol.6 (3), p.e14741 |
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| language | eng |
| recordid | cdi_plos_journals_1295455733 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Anemia Antigens CD36 antigen CD36 Antigens - metabolism Cell Adhesion - genetics Child Child, Preschool Clinical medicine Endothelium Erythrocytes Gene expression Genotype Host-Parasite Interactions Humans Infant Infections Infectious Diseases/Protozoal Infections Inflammation Intercellular adhesion molecule 1 Intercellular Adhesion Molecule-1 - metabolism Laboratories Ligands Malaria Malaria, Falciparum - parasitology Malaria, Falciparum - pathology Medical research Medicine Microbiology/Immunity to Infections Mutation Parasites Parasitology Pathology Plasmodium falciparum Plasmodium falciparum - cytology Plasmodium falciparum - genetics Plasmodium falciparum - isolation & purification Proteins Public Health and Epidemiology/Infectious Diseases Receptors Studies Tumor necrosis factor-TNF Vector-borne diseases |
| title | Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T00%3A08%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Specific%20receptor%20usage%20in%20Plasmodium%20falciparum%20cytoadherence%20is%20associated%20with%20disease%20outcome&rft.jtitle=PloS%20one&rft.au=Ochola,%20Lucy%20B&rft.date=2011-03-03&rft.volume=6&rft.issue=3&rft.spage=e14741&rft.pages=e14741-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0014741&rft_dat=%3Cgale_plos_%3EA476903464%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1295455733&rft_id=info:pmid/21390226&rft_galeid=A476903464&rft_doaj_id=oai_doaj_org_article_560b6f168c5a46409f8e822494c2c673&rfr_iscdi=true |