IKKα contributes to canonical NF-κB activation downstream of Nod1-mediated peptidoglycan recognition

During pathogen infection, innate immunity is initiated via the recognition of microbial products by pattern recognition receptors and the subsequent activation of transcription factors that upregulate proinflammatory genes. By controlling the expression of cytokines, chemokines, anti-bacterial pept...

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Veröffentlicht in:	PloS one 2010-10, Vol.5 (10), p.e15371-e15371
Hauptverfasser:	Kim, Man Lyang, Jeong, Hyun Gyeong, Kasper, Christoph Alexander, Arrieumerlou, Cécile
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiinfectives and antibacterials Arthritis Asthma Bacteria Bacterial diseases Base Sequence Biodegradation Biology Blotting, Western Catalysis Chemokines Cytokines Degradation Dimers DNA Primers Downstream effects Enzyme-Linked Immunosorbent Assay Epithelial cells Gene expression HeLa Cells Humans I-kappa B Kinase - metabolism Immunity Immunology Infections Inflammation Inflammatory diseases Innate immunity Interleukin Interleukin 8 Kinases Ligands Microorganisms NF-kappa B - metabolism NF-κB protein Nod1 protein Nod1 Signaling Adaptor Protein - metabolism Nuclear transport Pathogens Pattern recognition Pattern recognition receptors Peptides Peptidoglycan - metabolism Peptidoglycans Phosphorylation Proteins Proteomes Receptors Ribonucleic acid RNA RNA Interference RNA-mediated interference Signaling Transcription activation Transcription factors Translocation
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