Loss of 'small-world' networks in Alzheimer's disease: graph analysis of FMRI resting-state functional connectivity

Local network connectivity disruptions in Alzheimer's disease patients have been found using graph analysis in BOLD fMRI. Other studies using MEG and cortical thickness measures, however, show more global long distance connectivity changes, both in functional and structural imaging data. The fo...

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Veröffentlicht in:	PloS one 2010-11, Vol.5 (11), p.e13788-e13788
Hauptverfasser:	Sanz-Arigita, Ernesto J, Schoonheim, Menno M, Damoiseaux, Jessica S, Rombouts, Serge A R B, Maris, Erik, Barkhof, Frederik, Scheltens, Philip, Stam, Cornelis J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Advertising executives Age Aged Aged, 80 and over Algorithms Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer's disease Attention deficit hyperactivity disorder Brain Brain - pathology Brain - physiopathology Brain mapping Brain Mapping - methods Clusters Cognition & reasoning Cognitive ability Computational Biology/Computational Neuroscience Cortex Dementia Departments Female Functional magnetic resonance imaging Humans Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medical research Memory Middle Aged Models, Neurological Nerve Net - pathology Nerve Net - physiopathology Networks Neural networks Neurodegenerative diseases Neuroimaging Neurological Disorders/Alzheimer Disease Neurology NMR Nuclear magnetic resonance Patients Radiology and Medical Imaging/Magnetic Resonance Imaging Regional analysis Rest Structure-function relationships Synchronism Synchronization Time synchronization Young Adult
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