Cyclophilin B interacts with sodium-potassium ATPase and is required for pump activity in proximal tubule cells of the kidney

Cyclophilins (Cyps), the intracellular receptors for Cyclosporine A (CsA), are responsible for peptidyl-prolyl cis-trans isomerisation and for chaperoning several membrane proteins. Those functions are inhibited upon CsA binding. Albeit its great benefits as immunosuppressant, the use of CsA has bee...

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Veröffentlicht in:	PloS one 2010-11, Vol.5 (11), p.e13930
Hauptverfasser:	Suñé, Guillermo, Sarró, Eduard, Puigmulé, Marta, López-Hellín, Joan, Zufferey, Madeleine, Pertel, Thomas, Luban, Jeremy, Meseguer, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Apoptosis ATPases Blotting, Western Breast cancer Cell Biology Cell Line, Transformed Chlorocebus aethiops Cloning Confocal microscopy COS Cells Cyclophilins - genetics Cyclophilins - metabolism Cyclosporine - pharmacology Cyclosporins Enzyme Inhibitors - pharmacology Fibrosis Gangrene HEK293 Cells Humans Hyperkalemia Hypertension Immunoprecipitation Immunosuppressive agents Isomerization Kidney transplantation Kidney Tubules, Proximal - cytology Kidney Tubules, Proximal - metabolism Maturation Medical screening Membrane proteins Microscopy Molecular Biology Molecular modelling Na+/K+-exchanging ATPase Nephrology/Renal Physiology Pathogenesis Peptidylprolyl isomerase Phenols Polyclonal antibodies Potassium Protein Binding - drug effects Protein Subunits - genetics Protein Subunits - metabolism Proteins Receptors Renal failure Reverse Transcriptase Polymerase Chain Reaction RNA Interference Rodents Routing Screens Sodium Sodium-Potassium-Exchanging ATPase - genetics Sodium-Potassium-Exchanging ATPase - metabolism Toxicity Transcription factors Transplants & implants Two-Hybrid System Techniques Yeast
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