Neutrophils reduce the parasite burden in Leishmania (Leishmania) amazonensis-infected macrophages

Studies on the role of neutrophils in Leishmania infection were mainly performed with L. (L) major, whereas less information is available for L. (L) amazonensis. Previous results from our laboratory showed a large infiltrate of neutrophils in the site of infection in a mouse strain resistant to L. (...

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Veröffentlicht in:	PloS one 2010-11, Vol.5 (11), p.e13815
Hauptverfasser:	de Souza Carmo, Erico Vinícius, Katz, Simone, Barbiéri, Clara Lúcia
Format:	Artikel
Sprache:	eng
Schlagworte:	Amastigotes Amino Acid Chloromethyl Ketones - pharmacology Animals Antibodies - immunology Antibodies - pharmacology Azepines - pharmacology Cell activation Cell Communication - immunology Cells, Cultured Classical pathway Coculture Techniques Cytokines Cytokines - immunology Cytokines - metabolism Cytotoxicity Destruction Elastase Enzymes Female Free radicals Granulocytes Health aspects Host-Parasite Interactions - drug effects Immunity Immunology/Immunity to Infections Immunology/Innate Immunity In vitro methods and tests Infection Infections Infectious Diseases/Neglected Tropical Diseases Infectious Diseases/Protozoal Infections Inflammation Innate immunity Leishmania Leishmania - physiology Leishmania amazonensis Leishmania major Leukocyte Elastase - antagonists & inhibitors Leukocyte Elastase - metabolism Leukocytes (neutrophilic) Macrophages Macrophages, Peritoneal - immunology Macrophages, Peritoneal - metabolism Macrophages, Peritoneal - parasitology Metabolism Metabolites Mice Mice, Inbred BALB C Mice, Inbred C3H Microscopy Microscopy, Fluorescence Neutrophils Neutrophils - cytology Neutrophils - immunology Neutrophils - metabolism Nitric Oxide - metabolism Nitrogen radicals Oxygen Parasites Peritoneum Platelet Activating Factor - antagonists & inhibitors Platelet Activating Factor - metabolism Platelet-activating factor Reactive Oxygen Species - metabolism Rodents Triazoles - pharmacology Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α
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