Evaluation of the association between the AC3 genetic polymorphisms and obesity in a Chinese Han population
AC3 is one of adenylyl cyclase isoforms involved in cAMP and insulin signaling pathway. Recent reports have demonstrated that the AC3 genetic polymorphisms are associated with obesity in a Swedish population. AC3 knock out mice exhibit obese when they age. These findings suggest that AC3 plays an im...
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| creator | Wang, Hairu Wu, Ming Zhu, Weiguang Shen, Jin Shi, Xiaoming Yang, Jie Zhao, Qihui Ni, Chuan Xu, Yaochu Shen, Hongbing Shen, Chong Gu, Harvest F |
| description | AC3 is one of adenylyl cyclase isoforms involved in cAMP and insulin signaling pathway. Recent reports have demonstrated that the AC3 genetic polymorphisms are associated with obesity in a Swedish population. AC3 knock out mice exhibit obese when they age. These findings suggest that AC3 plays an important role in the regulation of body weight.
In the present study, we evaluated the association between the AC3 genetic polymorphisms and obesity in a Han Chinese population. A total of 2580 adults, including 1490 lean (BMI = 18.5-23.9), 677 overweight (BMI 24.0-27.9) and 413 obese (BMI ≥28.0) subjects were genotyped for 5 TagSNPs in the AC3 gene. Single maker association analyses indicated that SNP rs753529 was significantly associated with BMI in obese subjects (P = 0.022, OR = 0.775 95%CI = 0.623-0.963), but not in overweight subjects (P = 0.818). Multiple maker association analyses showed that the haplotype (G-G-G) constructed with SNPs rs1127568, rs7604576 and rs753529 was significantly associated with obesity (P = 0.029). Further genotyping of SNP rs753529 in 816 children, including 361 overweight subjects (BMI>P(80)) and 455 controls (BMI = P(20-50)) were performed, and no significant association with BMI was found. All tests were adjusted for age, sex, physical activity index, household income and/or diet expenses.
The present study provides replication evidence that the AC3 genetic polymorphisms are associated with decreased risk of obesity among adults but not in children in a Chinese Han population. The data also suggest that the AC3 genetic effects on BMI may have interaction with the factors related to ageing and environment. |
| doi_str_mv | 10.1371/journal.pone.0013851 |
| format | Article |
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In the present study, we evaluated the association between the AC3 genetic polymorphisms and obesity in a Han Chinese population. A total of 2580 adults, including 1490 lean (BMI = 18.5-23.9), 677 overweight (BMI 24.0-27.9) and 413 obese (BMI ≥28.0) subjects were genotyped for 5 TagSNPs in the AC3 gene. Single maker association analyses indicated that SNP rs753529 was significantly associated with BMI in obese subjects (P = 0.022, OR = 0.775 95%CI = 0.623-0.963), but not in overweight subjects (P = 0.818). Multiple maker association analyses showed that the haplotype (G-G-G) constructed with SNPs rs1127568, rs7604576 and rs753529 was significantly associated with obesity (P = 0.029). Further genotyping of SNP rs753529 in 816 children, including 361 overweight subjects (BMI>P(80)) and 455 controls (BMI = P(20-50)) were performed, and no significant association with BMI was found. All tests were adjusted for age, sex, physical activity index, household income and/or diet expenses.
The present study provides replication evidence that the AC3 genetic polymorphisms are associated with decreased risk of obesity among adults but not in children in a Chinese Han population. The data also suggest that the AC3 genetic effects on BMI may have interaction with the factors related to ageing and environment.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0013851</identifier><identifier>PMID: 21079816</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adenylate cyclase ; Adenylyl Cyclases - genetics ; Adolescent ; Adult ; Adults ; Age ; Analysis ; Asian Continental Ancestry Group - genetics ; Body mass ; Body Mass Index ; Body weight ; Cardiovascular disease ; Child ; Child, Preschool ; Children ; China ; Chronic illnesses ; Costs ; Cyclic adenosine monophosphate ; Diabetes ; Diabetes and Endocrinology/Obesity ; Disease control ; Epidemiology ; Exercise ; Families & family life ; Family income ; Female ; Gene Frequency ; Genetic aspects ; Genetic effects ; Genetic polymorphisms ; Genetic Predisposition to Disease - genetics ; Genotype ; Genotyping ; Glucose ; Haplotypes ; Homeostasis ; Humans ; Insulin ; Isoenzymes - genetics ; Isoforms ; Linkage Disequilibrium ; Male ; Medicin och hälsovetenskap ; Middle Aged ; Obesity ; Obesity - enzymology ; Obesity - ethnology ; Obesity - genetics ; Overweight ; Pediatrics and Child Health/Adolescent Medicine ; Physical activity ; Polymorphism, Single Nucleotide ; Population ; Public health ; Public Health and Epidemiology/Epidemiology ; Questionnaires ; Risk Assessment ; Risk Factors ; Signal transduction ; Signaling ; Single-nucleotide polymorphism ; Tumors ; Type 2 diabetes ; Weight control ; Young Adult</subject><ispartof>PloS one, 2010-11, Vol.5 (11), p.e13851-e13851</ispartof><rights>COPYRIGHT 2010 Public Library of Science</rights><rights>2010 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Wang et al. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c811t-84ced092116a97300814577c47095132bd2d90e836987e896e5fbb09a2e078e53</citedby><cites>FETCH-LOGICAL-c811t-84ced092116a97300814577c47095132bd2d90e836987e896e5fbb09a2e078e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973974/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973974/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,552,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21079816$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:121592662$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><contributor>Vella, Adrian</contributor><creatorcontrib>Wang, Hairu</creatorcontrib><creatorcontrib>Wu, Ming</creatorcontrib><creatorcontrib>Zhu, Weiguang</creatorcontrib><creatorcontrib>Shen, Jin</creatorcontrib><creatorcontrib>Shi, Xiaoming</creatorcontrib><creatorcontrib>Yang, Jie</creatorcontrib><creatorcontrib>Zhao, Qihui</creatorcontrib><creatorcontrib>Ni, Chuan</creatorcontrib><creatorcontrib>Xu, Yaochu</creatorcontrib><creatorcontrib>Shen, Hongbing</creatorcontrib><creatorcontrib>Shen, Chong</creatorcontrib><creatorcontrib>Gu, Harvest F</creatorcontrib><title>Evaluation of the association between the AC3 genetic polymorphisms and obesity in a Chinese Han population</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>AC3 is one of adenylyl cyclase isoforms involved in cAMP and insulin signaling pathway. Recent reports have demonstrated that the AC3 genetic polymorphisms are associated with obesity in a Swedish population. AC3 knock out mice exhibit obese when they age. These findings suggest that AC3 plays an important role in the regulation of body weight.
In the present study, we evaluated the association between the AC3 genetic polymorphisms and obesity in a Han Chinese population. A total of 2580 adults, including 1490 lean (BMI = 18.5-23.9), 677 overweight (BMI 24.0-27.9) and 413 obese (BMI ≥28.0) subjects were genotyped for 5 TagSNPs in the AC3 gene. Single maker association analyses indicated that SNP rs753529 was significantly associated with BMI in obese subjects (P = 0.022, OR = 0.775 95%CI = 0.623-0.963), but not in overweight subjects (P = 0.818). Multiple maker association analyses showed that the haplotype (G-G-G) constructed with SNPs rs1127568, rs7604576 and rs753529 was significantly associated with obesity (P = 0.029). Further genotyping of SNP rs753529 in 816 children, including 361 overweight subjects (BMI>P(80)) and 455 controls (BMI = P(20-50)) were performed, and no significant association with BMI was found. All tests were adjusted for age, sex, physical activity index, household income and/or diet expenses.
The present study provides replication evidence that the AC3 genetic polymorphisms are associated with decreased risk of obesity among adults but not in children in a Chinese Han population. The data also suggest that the AC3 genetic effects on BMI may have interaction with the factors related to ageing and environment.</description><subject>Adenylate cyclase</subject><subject>Adenylyl Cyclases - genetics</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Adults</subject><subject>Age</subject><subject>Analysis</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Body weight</subject><subject>Cardiovascular disease</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>China</subject><subject>Chronic illnesses</subject><subject>Costs</subject><subject>Cyclic adenosine monophosphate</subject><subject>Diabetes</subject><subject>Diabetes and Endocrinology/Obesity</subject><subject>Disease control</subject><subject>Epidemiology</subject><subject>Exercise</subject><subject>Families & family life</subject><subject>Family income</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic aspects</subject><subject>Genetic effects</subject><subject>Genetic polymorphisms</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Genotyping</subject><subject>Glucose</subject><subject>Haplotypes</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Insulin</subject><subject>Isoenzymes - genetics</subject><subject>Isoforms</subject><subject>Linkage Disequilibrium</subject><subject>Male</subject><subject>Medicin och hälsovetenskap</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - enzymology</subject><subject>Obesity - ethnology</subject><subject>Obesity - genetics</subject><subject>Overweight</subject><subject>Pediatrics and Child Health/Adolescent Medicine</subject><subject>Physical activity</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population</subject><subject>Public health</subject><subject>Public Health and Epidemiology/Epidemiology</subject><subject>Questionnaires</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Signal transduction</subject><subject>Signaling</subject><subject>Single-nucleotide polymorphism</subject><subject>Tumors</subject><subject>Type 2 diabetes</subject><subject>Weight control</subject><subject>Young 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one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Hairu</au><au>Wu, Ming</au><au>Zhu, Weiguang</au><au>Shen, Jin</au><au>Shi, Xiaoming</au><au>Yang, Jie</au><au>Zhao, Qihui</au><au>Ni, Chuan</au><au>Xu, Yaochu</au><au>Shen, Hongbing</au><au>Shen, Chong</au><au>Gu, Harvest F</au><au>Vella, Adrian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the association between the AC3 genetic polymorphisms and obesity in a Chinese Han population</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2010-11-04</date><risdate>2010</risdate><volume>5</volume><issue>11</issue><spage>e13851</spage><epage>e13851</epage><pages>e13851-e13851</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>AC3 is one of adenylyl cyclase isoforms involved in cAMP and insulin signaling pathway. Recent reports have demonstrated that the AC3 genetic polymorphisms are associated with obesity in a Swedish population. AC3 knock out mice exhibit obese when they age. These findings suggest that AC3 plays an important role in the regulation of body weight.
In the present study, we evaluated the association between the AC3 genetic polymorphisms and obesity in a Han Chinese population. A total of 2580 adults, including 1490 lean (BMI = 18.5-23.9), 677 overweight (BMI 24.0-27.9) and 413 obese (BMI ≥28.0) subjects were genotyped for 5 TagSNPs in the AC3 gene. Single maker association analyses indicated that SNP rs753529 was significantly associated with BMI in obese subjects (P = 0.022, OR = 0.775 95%CI = 0.623-0.963), but not in overweight subjects (P = 0.818). Multiple maker association analyses showed that the haplotype (G-G-G) constructed with SNPs rs1127568, rs7604576 and rs753529 was significantly associated with obesity (P = 0.029). Further genotyping of SNP rs753529 in 816 children, including 361 overweight subjects (BMI>P(80)) and 455 controls (BMI = P(20-50)) were performed, and no significant association with BMI was found. All tests were adjusted for age, sex, physical activity index, household income and/or diet expenses.
The present study provides replication evidence that the AC3 genetic polymorphisms are associated with decreased risk of obesity among adults but not in children in a Chinese Han population. The data also suggest that the AC3 genetic effects on BMI may have interaction with the factors related to ageing and environment.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21079816</pmid><doi>10.1371/journal.pone.0013851</doi><tpages>e13851</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2010-11, Vol.5 (11), p.e13851-e13851 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1295122911 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adenylate cyclase Adenylyl Cyclases - genetics Adolescent Adult Adults Age Analysis Asian Continental Ancestry Group - genetics Body mass Body Mass Index Body weight Cardiovascular disease Child Child, Preschool Children China Chronic illnesses Costs Cyclic adenosine monophosphate Diabetes Diabetes and Endocrinology/Obesity Disease control Epidemiology Exercise Families & family life Family income Female Gene Frequency Genetic aspects Genetic effects Genetic polymorphisms Genetic Predisposition to Disease - genetics Genotype Genotyping Glucose Haplotypes Homeostasis Humans Insulin Isoenzymes - genetics Isoforms Linkage Disequilibrium Male Medicin och hälsovetenskap Middle Aged Obesity Obesity - enzymology Obesity - ethnology Obesity - genetics Overweight Pediatrics and Child Health/Adolescent Medicine Physical activity Polymorphism, Single Nucleotide Population Public health Public Health and Epidemiology/Epidemiology Questionnaires Risk Assessment Risk Factors Signal transduction Signaling Single-nucleotide polymorphism Tumors Type 2 diabetes Weight control Young Adult |
| title | Evaluation of the association between the AC3 genetic polymorphisms and obesity in a Chinese Han population |
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