Preferential localization of human origins of DNA replication at the 5'-ends of expressed genes and at evolutionarily conserved DNA sequences

Replication of mammalian genomes requires the activation of thousands of origins which are both spatially and temporally regulated by as yet unknown mechanisms. At the most fundamental level, our knowledge about the distribution pattern of origins in each of the chromosomes, among different cell typ...

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Veröffentlicht in:	PloS one 2011-05, Vol.6 (5), p.e17308-e17308
Hauptverfasser:	Valenzuela, Manuel S, Chen, Yidong, Davis, Sean, Yang, Fan, Walker, Robert L, Bilke, Sven, Lueders, John, Martin, Melvenia M, Aladjem, Mirit I, Massion, Pierre P, Meltzer, Paul S
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Flanking Region - genetics Activation Base Sequence Binding Sites Biology Biotechnology Breast cancer Cancer Cell Line Chromatin Chromatin - metabolism Chromosomes Conserved Sequence Deoxyribonucleic acid DNA DNA biosynthesis DNA probes DNA replication DNA Replication - genetics DNA sequencing DNA, Intergenic - genetics DNA-directed RNA polymerase Enrichment Evolution Evolution, Molecular Exonuclease Gene Expression Gene sequencing Genes Genomes Genomics Human evolution Humans Hybridization Laboratories Localization Lymphoma Medical research Nucleotide sequence Origins Physiological aspects Replication Replication initiation Replication Origin - genetics Replication origins Ribonucleic acid RNA RNA polymerase II Stochastic processes Stochasticity Tiling Transcription initiation Yeast
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