Hepatitis B virus lacks immune activating capacity, but actively inhibits plasmacytoid dendritic cell function

Chronic hepatitis B virus (HBV) infection is caused by inadequate anti-viral immunity. Activation of plasmacytoid dendritic cells (pDC) leading to IFNα production is important for effective anti-viral immunity. Hepatitis B virus (HBV) infection lacks IFNα induction in animal models and patients and...

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Veröffentlicht in:	PloS one 2011-01, Vol.6 (1), p.e15324-e15324
Hauptverfasser:	Woltman, Andrea M, Op den Brouw, Marjoleine L, Biesta, Paula J, Shi, Cui C, Janssen, Harry L A
Format:	Artikel
Sprache:	eng
Schlagworte:	Active control Animal models Antigens Antiviral agents Biology Case-Control Studies Cell activation Cell Communication - immunology Cells, Cultured Chronic infection Comparative analysis CpG islands Cytokines Dendritic cells Dendritic Cells - immunology Dendritic Cells - virology Deoxyribonucleic acid DNA Gastroenterology Gene expression Health aspects Hepatitis Hepatitis B Hepatitis B e antigen Hepatitis B surface antigen Hepatitis B virus Hepatitis B virus - immunology Hepatology Humans Immunity Immunosuppression Infection Infections Influenza Interferon Interferon regulatory factor 7 Interleukin 6 IP-10 protein Killer cells Ligands Liver Lymphocytes B Medical research Medicine Monocytes Monocytes - immunology Natural killer cells Patients Phosphorylation Proteins TLR7 protein TLR9 protein Toll-like receptors TOR protein Transcription Transcription (Genetics) Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics Tumor necrosis factor-α Viral infections Viral Proteins - pharmacology Viruses
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