Pressure load: the main factor for altered gene expression in right ventricular hypertrophy in chronic hypoxic rats

The present study investigated whether changes in gene expression in the right ventricle following pulmonary hypertension can be attributed to hypoxia or pressure loading. To distinguish hypoxia from pressure-induced alterations, a group of rats underwent banding of the pulmonary trunk (PTB), sham o...

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Veröffentlicht in:	PloS one 2011-01, Vol.6 (1), p.e15859-e15859
Hauptverfasser:	Baandrup, Jonas D, Markvardsen, Lars H, Peters, Christian D, Schou, Uffe K, Jensen, Jens L, Magnusson, Nils E, Ørntoft, Torben F, Kruhøffer, Mogens, Simonsen, Ulf
Format:	Artikel
Sprache:	eng
Schlagworte:	Amine oxidase (flavin-containing) Animals Apoptosis Banding Biochemistry Biology Blood Pressure Body weight c-Kit protein Cardiomyocytes Fatty acids Gene expression Gene Expression Profiling Gene Expression Regulation - physiology Genes Glycerol Growth factors Heart Heart hypertrophy Hypertension Hypertension, Pulmonary - genetics Hypertrophy Hypertrophy, Right Ventricular - genetics Hypoxia Hypoxia - genetics Immunoblotting Insulin Kinases Laboratory animals Localization Medical prognosis Medicine Monoamine oxidase Nervous system Nitric oxide Oxidation Pharmacology Pressure measurement Pressure measurements Protein binding Protein-tyrosine kinase Proteins Pulmonary arteries Pulmonary hypertension Rats Rodents Serotonin Signal transduction Transglutaminase 2 Tyrosine Veins & arteries Ventricle
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