Metabolic changes in skin caused by Scd1 deficiency: a focus on retinol metabolism

We previously reported that mice with skin-specific deletion of stearoyl-CoA desaturase-1 (Scd1) recapitulated the skin phenotype and hypermetabolism observed in mice with a whole-body deletion of Scd1. In this study, we first performed a diet-induced obesity experiment at thermoneutral temperature...

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Veröffentlicht in:	PloS one 2011-05, Vol.6 (5), p.e19734
Hauptverfasser:	Flowers, Matthew T, Paton, Chad M, O'Byrne, Sheila M, Schiesser, Kevin, Dawson, John A, Blaner, William S, Kendziorski, Christina, Ntambi, James M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Proteins - genetics Acute-Phase Proteins - metabolism Animals Bayesian analysis Biochemistry Bioinformatics Biology Cholesterol Desaturase Desaturation DNA binding proteins DNA microarrays Elongation Epidermis - drug effects Epidermis - pathology Fatty acid synthesis Fatty acids Fatty Acids - biosynthesis Gene expression Gene Expression Profiling Genes Genomes Genotype & phenotype Hair Hair - drug effects Hair - metabolism Hair - pathology Health informatics Homeostasis House mouse Hyperplasia Hypoplasia Inflammation Inflammation - complications Inflammation - genetics Inflammation - pathology Lipids Lipocalin-2 Lipocalins - genetics Lipocalins - metabolism Male Mass spectrometry Medicine Metabolism Mice Mice, Knockout Nutrition Obesity Obesity - metabolism Obesity - pathology Oligonucleotide Array Sequence Analysis Oncogene Proteins - genetics Oncogene Proteins - metabolism Physiological aspects PPAR delta - metabolism Receptors, Retinoic Acid - genetics Receptors, Retinoic Acid - metabolism Retinoic acid Retinoids Rodents Scientific imaging Sebaceous gland Sebaceous Glands - abnormalities Sebaceous Glands - metabolism Sebaceous Glands - pathology Skin Skin - metabolism Skin resistance Stearoyl-CoA desaturase Stearoyl-CoA Desaturase - deficiency Stearoyl-CoA Desaturase - metabolism Sterols Sterols - metabolism Studies Synthesis Temperature Transcription (Genetics) Transcription factors Transcription Factors - metabolism Transcriptional Activation - drug effects Transcriptional Activation - genetics Tretinoin - pharmacology Triglycerides Vitamin A Vitamin A - metabolism
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