A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint

A combined computational and biochemical approach reveals how mitotic kinases allow cell division to proceed in the presence of DNA damage. DNA damage checkpoints arrest cell cycle progression to facilitate DNA repair. The ability to survive genotoxic insults depends not only on the initiation of ce...

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Veröffentlicht in:	PLoS biology 2010-01, Vol.8 (1), p.e1000287
Hauptverfasser:	van Vugt, Marcel A. T. M., Gardino, Alexandra K., Linding, Rune, Ostheimer, Gerard J., Reinhardt, H. Christian, Ong, Shao-En, Tan, Chris S., Miao, Hua, Keezer, Susan M., Li, Jeijin, Pawson, Tony, Lewis, Timothy A., Carr, Steven A., Smerdon, Stephen J., Brummelkamp, Thijn R., Yaffe, Michael B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry/Cell Signaling and Trafficking Structures Cell Biology/Cell Growth and Division Cell Biology/Cell Signaling Cell cycle DNA damage DNA repair Mutation Proteins
Online-Zugang:	Volltext
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