Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells

Natural T regulatory cells (Tregs) are challenging to expand ex vivo, and this has severely hindered in vivo evaluation of their therapeutic potential. All trans retinoic acid (ATRA) plays an important role in mediating immune homeostasis in vivo, and we investigated whether ATRA could be used to pr...

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Veröffentlicht in:	PloS one 2011-01, Vol.6 (1), p.e15868
Hauptverfasser:	Golovina, Tatiana N, Mikheeva, Tatiana, Brusko, Todd M, Blazar, Bruce R, Bluestone, Jeffrey A, Riley, James L
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Biology Bone marrow Cancer CD45RA antigen Cell Culture Techniques - methods Cell Proliferation - drug effects Coculture Techniques Cytokines Cytokines - biosynthesis Diabetes DNA methylation Drug Synergism Effector cells Expansion Forkhead Transcription Factors - analysis Foxp3 protein Good Manufacturing Practice Health aspects Homeostasis Humans Immunoregulation In vivo methods and tests Kinases Laboratories Lymphocytes Lymphocytes T Medical research Medicine Pathology Pediatrics Peripheral blood Polyphenols Rapamycin Regulation Retinoic acid Rodents Sirolimus - pharmacology T cell receptors T cells T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - drug effects Transcription factors Transplants & implants Tretinoin Tretinoin - pharmacology Vitamin A
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