T cells from Programmed Death-1 deficient mice respond poorly to Mycobacterium tuberculosis infection

Programmed Death-1 (PD-1; CD279) receptor molecule is widely believed to be a negative regulator predominantly expressed by exhausted/activated mouse T cells. Upon interaction with its ligands, PD-L1 and PD-L2, PD-1 inhibits activation of T cells and cytokine production, which has been documented in...

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Veröffentlicht in:	PloS one 2011-05, Vol.6 (5), p.e19864-e19864
Hauptverfasser:	Tousif, Sultan, Singh, Yogesh, Prasad, Durbaka Vijaya Raghava, Sharma, Pawan, Van Kaer, Luc, Das, Gobardhan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antigens Apoptosis Autophagy B cells Biology Cell activation Cell death Cell Proliferation Comparative analysis Cytokines Disease resistance Escherichia coli Flow Cytometry Genetic engineering Health aspects Immunoregulation Infections Lymphocytes Lymphocytes T Macrophages Macrophages - immunology Medical research Medicine Mesenchyme Mice Mice, Inbred C57BL Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Mycoses PD-1 protein PD-L1 protein Phagocytosis Risk factors Rodents Stem cell transplantation Stem cells Studies T cell receptors T cells T-Lymphocytes - immunology Tuberculosis Tuberculosis - immunology Tuberculosis - microbiology
Online-Zugang:	Volltext
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