Up-regulation of sonic hedgehog contributes to TGF-β1-induced epithelial to mesenchymal transition in NSCLC cells

Lung cancer, especially non-small cell lung cancer (NSCLC) is the major cause of cancer-related deaths in the United States. The aggressiveness of NSCLC has been shown to be associated with the acquisition of epithelial-to-mesenchymal transition (EMT). The acquisition of EMT phenotype induced by TGF...

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Veröffentlicht in:	PloS one 2011-01, Vol.6 (1), p.e16068
Hauptverfasser:	Maitah, Ma'in Y, Ali, Shadan, Ahmad, Aamir, Gadgeel, Shirish, Sarkar, Fazlul H
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggressive behavior Cancer Cancer therapies Carcinoma, Non-Small-Cell Lung - pathology Cell growth Cell Line, Tumor Cell Movement Cell Proliferation Chronic exposure Cytotoxicity E-cadherin Epithelial-Mesenchymal Transition - drug effects Fibronectin Gene regulation Genes Genotype & phenotype Growth factors Hedgehog protein Hedgehog Proteins - biosynthesis Hedgehog Proteins - genetics Hematology Humans Inhibitors Internal medicine Kinases Leukemia Ligands Lung cancer Lung diseases Lung Neoplasms - pathology M cells Medicine Mesenchyme Mesothelioma Metastases Metastasis Non-small cell lung carcinoma Pathology Pharmacology Prostate cancer RNA, Messenger - analysis RNA, Messenger - biosynthesis Serotonin Signaling siRNA Stem cells Studies Transcription Transcription, Genetic - drug effects Transforming Growth Factor beta1 - pharmacology Transforming growth factor-b1 Trends Tumors Up-regulation Up-Regulation - drug effects Up-Regulation - genetics
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