K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism

HIV-1 carrying the "Q151M complex" reverse transcriptase (RT) mutations (A62V/V75I/F77L/F116Y/Q151M, or Q151Mc) is resistant to many FDA-approved nucleoside RT inhibitors (NRTIs), but has been considered susceptible to tenofovir disoproxil fumarate (TFV-DF or TDF). We have isolated from a...

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Veröffentlicht in:	PloS one 2011-01, Vol.6 (1), p.e16242-e16242
Hauptverfasser:	Hachiya, Atsuko, Kodama, Eiichi N, Schuckmann, Matthew M, Kirby, Karen A, Michailidis, Eleftherios, Sakagami, Yasuko, Oka, Shinichi, Singh, Kamalendra, Sarafianos, Stefan G
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adenine - analogs & derivatives Adenine - pharmacology AIDS Antiretroviral drugs Binding Biology Care and treatment Catalytic Domain Chain dynamics Chemical bonds Chemistry Computer Simulation Deoxyribonucleic acid Discrimination DNA DNA polymerases Drug approval Drug resistance Drug Resistance, Viral - genetics Enzymes HIV HIV - genetics HIV - isolation & purification HIV Reverse Transcriptase - genetics Human immunodeficiency virus Humans Hydrogen Hydrogen Bonding Kinetics Levels Medicine Molecular dynamics Multidrug resistance Mutation Mutation, Missense Organophosphonates - pharmacology Protease inhibitors Reverse Transcriptase Inhibitors - pharmacology RNA-directed DNA polymerase Tenofovir
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