Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia

Preeclampsia is a leading cause of perinatal morbidity and mortality. This disorder is thought to be multifactorial in origin, with multiple genes, environmental and social factors, contributing to disease. One proposed mechanism is placental hypoxia-driven imbalances in angiogenic and anti-angiogen...

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Veröffentlicht in:	PloS one 2011-01, Vol.6 (1), p.e16681-e16681
Hauptverfasser:	Hill, Lori D, York, Timothy P, Kusanovic, Juan P, Gomez, Ricardo, Eaves, Lindon J, Romero, Roberto, Strauss, 3rd, Jerome F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosylmethionine Alleles Angiogenesis Animals Biology Birth weight Blood pressure Catechol Catechol O-methyltransferase Catechol O-Methyltransferase - genetics Disease Endothelial cells Enzymatic activity Enzyme activity Enzymes Epistasis Epistasis, Genetic Estrogens Ethnicity Female Fetuses Gene polymorphism Genes Genetics Genomes Growth factors Gynecology Haplotypes Health aspects Hispanic Americans - genetics Humans Hypertension Hypoxia Medicine Metabolites Methylenetetrahydrofolate reductase Methylenetetrahydrofolate Reductase (NADPH2) - genetics Methyltransferase Mice Morbidity Mortality Mutation Obstetrics Panic attacks Placenta Polymorphism Polymorphism, Single Nucleotide Pre-eclampsia Pre-Eclampsia - genetics Preeclampsia Pregnancy Risk factors S-Adenosylmethionine Single nucleotide polymorphisms Single-nucleotide polymorphism Social factors Studies Variation Working groups
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