A randomized trial to assess anti-HIV activity in female genital tract secretions and soluble mucosal immunity following application of 1% tenofovir gel

Preclinical and early phase clinical microbicide studies have not consistently predicted the outcome of efficacy trials. To address this gap, candidate biomarkers of microbicide pharmacodynamics and safety were evaluated in a double-blind, placebo-controlled trial of tenofovir gel, the first microbi...

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Veröffentlicht in:	PloS one 2011-01, Vol.6 (1), p.e16475
Hauptverfasser:	Keller, Marla J, Madan, Rebecca P, Torres, N Merna, Fazzari, Melissa J, Cho, Sylvia, Kalyoussef, Sabah, Shust, Gail, Mesquita, Pedro M M, Louissaint, Nicolette, Chen, Jianmeng, Cohen, Hillel W, Diament, Erin C, Lee, Anna C, Soto-Torres, Lydia, Hendrix, Craig W, Herold, Betsy C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - administration & dosage Adenine - analogs & derivatives Adenine - immunology Adenine - pharmacology Adult Anti-HIV Agents - administration & dosage Anti-HIV Agents - immunology Anti-HIV Agents - pharmacology Antimicrobial activity Antimicrobial agents Antiretroviral drugs Antiviral activity Bioassays Bioindicators Biology Biomarkers Biomarkers - analysis Chromatography Clinical trials Double-Blind Method Drug dosages Drug-Related Side Effects and Adverse Reactions E coli Effectiveness Epidemiology Escherichia coli Female Genital tract Genitalia, Female - drug effects Genitalia, Female - immunology Genitalia, Female - secretion Gynecology HIV HIV Infections - drug therapy HIV Infections - immunology Human immunodeficiency virus Humans Immunity Immunity, Mucosal - drug effects Immunology Infections Inflammation Inflammatory response Mathematical models Medicine Migraine Mucosal immunity Mucous Membrane - drug effects Mucous Membrane - immunology Obstetrics Organophosphonates - administration & dosage Organophosphonates - immunology Organophosphonates - pharmacology Pediatrics Pharmacodynamics Pharmacology Prognosis Safety Secretions Semen Spectrum analysis Studies Tenofovir Vaginal Douching Viruses Young Adult
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