Truncation of the deubiquitinating domain of CYLD in myelomonocytic cells attenuates inflammatory responses

The cylindromatosis tumor suppressor (CYLD) is a deubiquitinating enzyme that has been implicated in various aspects of adaptive and innate immune responses. Nevertheless, the role of CYLD in the function of specific types of immune cells remains elusive. In this report we have used conditional gene...

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Veröffentlicht in:	PloS one 2011-01, Vol.6 (1), p.e16397-e16397
Hauptverfasser:	Tsagaratou, Ageliki, Kontoyiannis, Dimitris L, Mosialos, George
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B cells Biology Bone marrow Cell activation Chemokines Cysteine Endopeptidases Endotoxemia Enzymes Gene targeting Genomes Genotype & phenotype House mouse Immune response Immune system Immunity Immunology Inflammation Inflammation - prevention & control Inflammatory diseases Innate immunity Kinases Leukemia, Myelomonocytic, Chronic - enzymology Lipopolysaccharides Lipopolysaccharides - pharmacology Lymphocytes Macrophage Activation Macrophages Macrophages, Peritoneal Mice Monocytes Peritoneum Physiology Rodents Septic shock Shock Shock, Septic - prevention & control Spleen Studies Tumor suppressor genes Ubiquitination
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