The thioredoxin TRX-1 modulates the function of the insulin-like neuropeptide DAF-28 during dauer formation in Caenorhabditis elegans

Thioredoxins comprise a conserved family of redox regulators involved in many biological processes, including stress resistance and aging. We report that the C. elegans thioredoxin TRX-1 acts in ASJ head sensory neurons as a novel modulator of the insulin-like neuropeptide DAF-28 during dauer format...

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Veröffentlicht in:	PloS one 2011-01, Vol.6 (1), p.e16561-e16561
Hauptverfasser:	Fierro-González, Juan Carlos, Cornils, Astrid, Alcedo, Joy, Miranda-Vizuete, Antonio, Swoboda, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Biological activity Biology Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Down-regulation Environment Environmental conditions Gene Expression Regulation Gene Expression Regulation, Developmental Insulin Insulins Kinases Larva - genetics Larva - metabolism Larvae Mutants Mutation Nematodes Neurons Neurons - physiology Neuropeptides - physiology Proteins Receptor, Insulin - genetics Receptor, Insulin - metabolism Sensory neurons Signaling Thioredoxin Thioredoxins Thioredoxins - genetics Thioredoxins - metabolism Worms
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