Differences in reversion of resistance mutations to wild-type under structured treatment interruption and related increase in replication capacity

The CPCRA 064 study examined the effect of structured treatment interruption (STI) of up to 4 months followed by salvage treatment in patients failing therapy with multi-drug resistant HIV. We examined the relationship between the reversion rate of major reverse transcriptase (RT) resistance-associa...

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Veröffentlicht in:	PloS one 2011-01, Vol.6 (1), p.e14638
Hauptverfasser:	Paquet, Agnes C, Baxter, John, Weidler, Jodi, Lie, Yolanda, Lawrence, Jody, Kim, Rose, Bates, Michael, Coakley, Eoin, Chappey, Colombe
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Analysis Antiretroviral drugs Care and treatment Codons DNA polymerases Drug resistance Drug Resistance, Multiple - genetics Drug Resistance, Viral - genetics Genetic aspects Genotype HIV HIV Infections - drug therapy HIV-1 - genetics HIV-1 - physiology Human immunodeficiency virus Humans Interruption Kinetics Longitudinal Studies Multidrug resistance Mutagenesis Mutation Mutation, Missense Patients Replication Reversion RNA-Directed DNA Polymerase Salvage Virology Virology/Immunodeficiency Viruses Virology/Viral and Gene Regulation Virus Replication Viruses
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