Novel mouse model reveals distinct activity-dependent and -independent contributions to synapse development

The balanced action of both pre- and postsynaptic organizers regulates the formation of neuromuscular junctions (NMJ). The precise mechanisms that control the regional specialization of acetylcholine receptor (AChR) aggregation, guide ingrowing axons and contribute to correct synaptic patterning are...

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Veröffentlicht in:	PloS one 2011-01, Vol.6 (1), p.e16469-e16469
Hauptverfasser:	Pacifici, Pier Giorgio, Peter, Christoph, Yampolsky, Pessah, Koenen, Michael, McArdle, Joseph J, Witzemann, Veit
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Acetylcholine receptors Analysis Animal models Animals Apoptosis Axon guidance Axons Biology Cytokines Deoxyribonucleic acid Diaphragm Diaphragm (anatomy) Dispersal DNA Embryogenesis Embryonic development Embryonic growth stage Fetuses Homologous recombination Homology Innervation Medical research Mice Models, Animal Motor neurons Motor Neurons - chemistry Motor Neurons - metabolism Motor Neurons - ultrastructure Muscle Fibers, Skeletal Musculoskeletal system Mutant Proteins Mutation Neurobiology Neuromuscular Junction Neuromuscular junctions Neurosciences Phenotype Receptor Aggregation Receptors, Cholinergic - analysis Receptors, Cholinergic - genetics Receptors, Cholinergic - physiology Rodents Specialization Stem cells Synapses Synapses - metabolism Synapses - ultrastructure Synaptogenesis
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