Chronic respiratory aeroallergen exposure in mice induces epithelial-mesenchymal transition in the large airways

Chronic allergic asthma is characterized by Th2-polarized inflammation and leads to airway remodeling and fibrosis but the mechanisms involved are not clear. To determine whether epithelial-mesenchymal transition contributes to airway remodeling in asthma, we induced allergic airway inflammation in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2011-01, Vol.6 (1), p.e16175
Hauptverfasser:	Johnson, Jill R, Roos, Abraham, Berg, Tove, Nord, Magnus, Fuxe, Jonas
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Airway management Airway Remodeling - immunology Allergens Allergens - adverse effects Allergies Animals Asthma Asthma - pathology Biochemistry Biology Biophysics Bone morphogenetic proteins Cancer Cell fate Cell migration Cell Movement Chronic Disease Collagen Collagen (type I) Dermatophagoides pteronyssinus E-Cadherin Epithelial cells Epithelial-Mesenchymal Transition - immunology Epithelium Epithelium - immunology Epithelium - pathology Exposure Fate maps Fibroblasts Fibrosis Growth factors House dust Inflammation Intermediate filament proteins Intranasal administration Laboratories Lungs Lymphocytes T Medicine Mesenchyme Mice Nuclear transport Plasticity Proteins Pyroglyphidae - immunology R&D Repressors Research & development Respiratory System - immunology Respiratory System - pathology Respiratory tract diseases Smooth muscle Stem cells Thickening Transcription Transcription factors Transforming growth factor- beta 1 Transforming growth factor-b1 Transforming growth factors Translocation Vimentin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!