siRNA-mediated gene targeting in Aedes aegypti embryos reveals that frazzled regulates vector mosquito CNS development

Although mosquito genome projects uncovered orthologues of many known developmental regulatory genes, extremely little is known about the development of vector mosquitoes. Here, we investigate the role of the Netrin receptor frazzled (fra) during embryonic nerve cord development of two vector mosqui...

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Veröffentlicht in:	PloS one 2011-01, Vol.6 (1), p.e16730-e16730
Hauptverfasser:	Clemons, Anthony, Haugen, Morgan, Le, Christy, Mori, Akio, Tomchaney, Michael, Severson, David W, Duman-Scheel, Molly
Format:	Artikel
Sprache:	eng
Schlagworte:	Aedes - embryology Aedes - genetics Aedes - growth & development Aedes aegypti Analysis Animals Anopheles Anopheles gambiae Aquatic insects Artemia franciscana Arthropoda Axon guidance Axonogenesis Axons Biology Central nervous system Central Nervous System - growth & development Crustaceans Culicidae Dengue Dengue fever Drosophila Drosophila melanogaster Drosophila Proteins Embryogenesis Embryonic development Embryonic growth stage Embryos Gene expression Gene Expression Regulation, Developmental Gene targeting Gene Targeting - methods Genetic aspects Genetic vectors Genetics Genomes Genomics Hypotheses Insect Vectors Insects Laboratories Malaria Medicine Microinjection Molecular biology Mosquitoes Mutants Nervous system Netrin Receptors Neurogenesis Parhyale hawaiensis Plasmodium gallinaceum Receptors, Cell Surface - analysis Receptors, Cell Surface - physiology RNA, Small Interfering - genetics siRNA Systems development Vector-borne diseases Ventral nerve cord
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