ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2

Mutations within the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of familial and sporadic Parkinson's disease. The multidomain protein LRRK2 exhibits overall low GTPase and kinase activity in vitro. Here, we show that the rho guanine nucleotide exchange factor ARHGEF7 and the s...

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Veröffentlicht in:	PloS one 2010-10, Vol.5 (10), p.e13762-e13762
Hauptverfasser:	Haebig, Karina, Gloeckner, Christian Johannes, Miralles, Marta Garcia, Gillardon, Frank, Schulte, Claudia, Riess, Olaf, Ueffing, Marius, Biskup, Saskia, Bonin, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Amino acids Brain research Cdc42 protein Cell Line Cytoskeleton Downstream effects Exchanging Feedback control Genetic aspects Genetics and Genomics/Gene Function Genetics and Genomics/Medical Genetics GTP Guanine Guanine nucleotide exchange factor Guanine Nucleotide Exchange Factors - metabolism Guanosine triphosphatases Guanosine triphosphate Guanosinetriphosphatase Humans Hydrolysis In vitro methods and tests Kinases Leucine Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 LRRK2 protein Movement disorders Mutation Neurodegenerative diseases Neurological Disorders/Neurogenetics Neuroscience/Neurobiology of Disease and Regeneration Parkinson's disease Pathogenesis Phosphorylation Protein-Serine-Threonine Kinases - metabolism Recombinant Proteins - metabolism Rho Guanine Nucleotide Exchange Factors Rodents
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