Mycobacterium tuberculosis induces an atypical cell death mode to escape from infected macrophages

Macrophage cell death following infection with Mycobacterium tuberculosis plays a central role in tuberculosis disease pathogenesis. Certain attenuated strains induce extrinsic apoptosis of infected macrophages but virulent strains of M. tuberculosis suppress this host response. We previously report...

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Veröffentlicht in:	PloS one 2011-03, Vol.6 (3), p.e18367-e18367
Hauptverfasser:	Lee, Jinhee, Repasy, Teresa, Papavinasasundaram, Kadamba, Sassetti, Christopher, Kornfeld, Hardy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - physiology Bacilli bcl-2 Homologous Antagonist-Killer Protein - metabolism bcl-2-Associated X Protein - metabolism Biochemistry Biology Biosynthesis Cathepsins Cathepsins - metabolism Cell death Cells, Cultured Chromatography, High Pressure Liquid Cues Cytotoxicity Disease transmission Gene expression Health aspects Herpes viruses Homeodomain Proteins - metabolism Hydrogen-Ion Concentration Infections Intracellular Leprosy Lipid bilayers Lipids Macrophages Macrophages - cytology Macrophages - metabolism Macrophages - microbiology Medical schools Medicine Membrane Potential, Mitochondrial Mice Microscopy, Electron, Scanning Microscopy, Electron, Transmission Mitochondria Mortality Mycobacterium leprae Mycobacterium tuberculosis Mycobacterium tuberculosis - pathogenicity Necrosis - metabolism Pathogenesis Pathogens Phospholipids Physiology Proto-Oncogene Proteins - metabolism Pyroptosis Strains (organisms) Toxicity Transcription Factors - metabolism Tuberculosis Tumor necrosis factor-TNF Virulence Virulence (Microbiology)
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