Further improvements of the P. falciparum humanized mouse model

It has been shown previously that it is possible to obtain growth of Plasmodium falciparum in human erythrocytes grafted in mice lacking adaptive immune responses by controlling, to a certain extent, innate defences with liposomes containing clodronate (clo-lip). However, the reproducibility of thos...

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Veröffentlicht in:	PloS one 2011-03, Vol.6 (3), p.e18045-e18045
Hauptverfasser:	Arnold, Ludovic, Tyagi, Rajeev Kumar, Meija, Pedro, Swetman, Claire, Gleeson, James, Pérignon, Jean-Louis, Druilhe, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Aging Analysis Animal models Animals Antimalarials B cells Bacterial infections Biology Bisphosphonates Cells, Cultured Clodronic acid Combination drug therapy Drug development Drugs Erythrocytes Erythrocytes - immunology Erythrocytes - parasitology Humans Immune response Immunity, Innate - drug effects Immunodeficiency Immunosuppressive agents Immunosuppressive Agents - therapeutic use Infections Inflammation Inflammatory response Injections, Intravenous Inosine - therapeutic use Interleukin 12 Interleukin 2 Interleukin 2 receptors Interleukin Receptor Common gamma Subunit - genetics Intravenous administration Liposomes Malaria Mice Mice, Inbred BALB C Mice, Inbred NOD Mice, SCID Mutation Parasitemia Parasitemia - drug therapy Parasitemia - parasitology Parasites Plasmodium Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - immunology Plasmodium falciparum - pathogenicity Reproducibility Rodents Vaccines Vector-borne diseases
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