A transient homotypic interaction model for the influenza A virus NS1 protein effector domain

Influenza A virus NS1 protein is a multifunctional virulence factor consisting of an RNA binding domain (RBD), a short linker, an effector domain (ED), and a C-terminal 'tail'. Although poorly understood, NS1 multimerization may autoregulate its actions. While RBD dimerization seems functi...

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Veröffentlicht in:	PloS one 2011-03, Vol.6 (3), p.e17946
Hauptverfasser:	Kerry, Philip S, Ayllon, Juan, Taylor, Margaret A, Hass, Claudia, Lewis, Andrew, García-Sastre, Adolfo, Randall, Richard E, Hale, Benjamin G, Russell, Rupert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Automation Binding Biology Cell Line Computational Biology Conserved Sequence Crystal structure Crystallography Crystallography, X-Ray Dimerization Dimers Dogs Double-stranded RNA Health aspects Humans Infections Influenza Influenza A Influenza A virus - metabolism Interaction models Interferon-beta - genetics Medicine Models, Biological Monoclonal antibodies Monomers Mutant Proteins - chemistry Mutation - genetics NS1 protein Pliability Protein Binding Protein Multimerization Protein Structure, Secondary Protein Structure, Tertiary Proteins Ribonucleic acid RNA RNA, Viral - metabolism Switches Transcription factors Viral Nonstructural Proteins - antagonists & inhibitors Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - metabolism Virulence Virulence (Microbiology) Virulence factors Viruses
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