Dkk1 regulates ventral midbrain dopaminergic differentiation and morphogenesis

Dickkopf1 (Dkk1) is a Wnt/β-catenin inhibitor that participates in many processes during embryonic development. One of its roles during embryogenesis is to induce head formation, since Dkk1-null mice lack head structures anterior to midbrain. The Wnt/β-catenin pathway is also known to regulate diffe...

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Veröffentlicht in:	PloS one 2011-02, Vol.6 (2), p.e15786-e15786
Hauptverfasser:	Ribeiro, Diogo, Ellwanger, Kristina, Glagow, Désirée, Theofilopoulos, Spyridon, Corsini, Nina S, Martin-Villalba, Ana, Niehrs, Christof, Arenas, Ernest
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals Biochemistry Biology Biophysics Cell Count Cell Differentiation Colorectal cancer Differentiation Dkk1 protein Dopamine Dopamine receptors Dopaminergic Neurons - cytology Dopaminergic Neurons - metabolism Embryo cells Embryogenesis Embryology Embryonic growth stage Embryos Ethics Gene Expression Regulation, Developmental Humidity Intercellular Signaling Peptides and Proteins - deficiency Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Medical research Medicin och hälsovetenskap Mesencephalon Mesencephalon - cytology Mesencephalon - growth & development Mesencephalon - metabolism Mice Molecular biology Morphogenesis Mutation Neurobiology Neuroblasts Neurogenesis Neurons Neurosciences Nuclear Receptor Subfamily 4, Group A, Member 2 - metabolism Signal transduction Stem cell transplantation Stem cells Wnt protein Xenopus β-Catenin
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