Using nuclear receptor activity to stratify hepatocarcinogens

Nuclear receptors (NR) are a superfamily of ligand-activated transcription factors that control a range of cellular processes. Persistent stimulation of some NR is a non-genotoxic mechanism of rodent liver cancer with unclear relevance to humans. Here we report on a systematic analysis of new in vit...

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Veröffentlicht in:	PloS one 2011-02, Vol.6 (2), p.e14584
Hauptverfasser:	Shah, Imran, Houck, Keith, Judson, Richard S, Kavlock, Robert J, Martin, Matthew T, Reif, David M, Wambaugh, John, Dix, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Aromatic compounds Biocompatibility Biological activity Cancer Carcinogens Carcinogens - classification Carcinogens - toxicity Carcinoma, Hepatocellular - chemically induced Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Cell Biology/Chemical Biology of the Cell Cells, Cultured Chemicals Cluster analysis Clustering Contaminants Development and progression Disease Progression DNA binding proteins Drug Evaluation, Preclinical - methods Environmental effects Environmental protection Gastroenterology and Hepatology/Hepatology Gene expression Gene Expression - drug effects Gene Expression Profiling Gene Regulatory Networks - drug effects Genotoxicity High-Throughput Screening Assays - methods Histopathology Humans Kinases Lesions Ligands Liver Liver - drug effects Liver - metabolism Liver - pathology Liver cancer Liver Neoplasms - chemically induced Liver Neoplasms - genetics Liver Neoplasms - metabolism liver X receptors Metabolism Mice Microarray Analysis Molecular Biology Multivariate analysis Nuclear receptors Pathology/Histopathology Peroxisome proliferator-activated receptors Phosphatase Pollutants R&D Rats Receptors Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Cytoplasmic and Nuclear - physiology Research & development Retinoid X receptors Rodents Steroid hormone receptors Toxicity Toxicology Transcription factors
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