Activated protein synthesis and suppressed protein breakdown signaling in skeletal muscle of critically ill patients

Skeletal muscle mass is controlled by myostatin and Akt-dependent signaling on mammalian target of rapamycin (mTOR), glycogen synthase kinase 3β (GSK3β) and forkhead box O (FoxO) pathways, but it is unknown how these pathways are regulated in critically ill human muscle. To describe factors involved...

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Veröffentlicht in:	PloS one 2011-03, Vol.6 (3), p.e18090-e18090
Hauptverfasser:	Jespersen, Jakob G, Nedergaard, Anders, Reitelseder, Søren, Mikkelsen, Ulla R, Dideriksen, Kasper J, Agergaard, Jakob, Kreiner, Frederik, Pott, Frank C, Schjerling, Peter, Kjaer, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aging AKT protein Alcohol Amino acids Biology Blotting, Western Bone surgery Branched chain amino acids Breakdown Care and treatment Case-Control Studies Cell cycle Chain branching Comparative analysis Critical Illness Diabetes Diabetes therapy Dietary fiber Electrolytes Female Forkhead protein FOXO1 protein FOXO3 protein Gene expression Glucose Glycogen Glycogen synthase kinase 3 Glycogen synthesis Hospital patients Hospitals Humans Illnesses Inflammation Insulin Insulin-like growth factor I Insulin-like growth factors Interleukin Interleukin 6 Interleukins Kinases Male Medicine Metabolism Middle Aged Mortality Muscle Proteins - genetics Muscle Proteins - metabolism Muscle, Skeletal - metabolism Muscles Musculoskeletal system Myostatin Orthopedics Pathways Patients Phosphates Phosphorylation Polymerase chain reaction Protein binding Protein Biosynthesis Protein synthesis Protein turnover Proteins Proteolysis Rapamycin Reverse Transcriptase Polymerase Chain Reaction Ribosomal protein S6 Ribosomal protein S6 kinase RNA Rodents Sepsis Signal transduction Signal Transduction - genetics Signal Transduction - physiology Signaling Skeletal muscle Thigh TOR protein Translation (Genetics) Type 2 diabetes Western blotting
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