Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians
Age-related physiological changes in the gastrointestinal tract, as well as modifications in lifestyle, nutritional behaviour, and functionality of the host immune system, inevitably affect the gut microbiota, resulting in a greater susceptibility to infections. By using the Human Intestinal Tract C...
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| creator | Biagi, E Nylund, L Candela, M Ostan, R Bucci, L Pini, E Nikkïla, J Monti, D Satokari, R.M Franceschi, C Brigidi, P Vos, W.M. de |
| description | Age-related physiological changes in the gastrointestinal tract, as well as modifications in lifestyle, nutritional behaviour, and functionality of the host immune system, inevitably affect the gut microbiota, resulting in a greater susceptibility to infections.
By using the Human Intestinal Tract Chip (HITChip) and quantitative PCR of 16S rRNA genes of Bacteria and Archaea, we explored the age-related differences in the gut microbiota composition among young adults, elderly, and centenarians, i.e subjects who reached the extreme limits of the human lifespan, living for over 100 years. We observed that the microbial composition and diversity of the gut ecosystem of young adults and seventy-years old people is highly similar but differs significantly from that of the centenarians. After 100 years of symbiotic association with the human host, the microbiota is characterized by a rearrangement in the Firmicutes population and an enrichment in facultative anaerobes, notably pathobionts. The presence of such a compromised microbiota in the centenarians is associated with an increased inflammatory status, also known as inflammageing, as determined by a range of peripheral blood inflammatory markers. This may be explained by a remodelling of the centenarians' microbiota, with a marked decrease in Faecalibacterium prauznitzii and relatives, symbiotic species with reported anti-inflammatory properties. As signature bacteria of the long life we identified specifically Eubacterium limosum and relatives that were more than ten-fold increased in the centenarians.
We provide evidence for the fact that the ageing process deeply affects the structure of the human gut microbiota, as well as its homeostasis with the host's immune system. Because of its crucial role in the host physiology and health status, age-related differences in the gut microbiota composition may be related to the progression of diseases and frailty in the elderly population. |
| doi_str_mv | 10.1371/journal.pone.0010667 |
| format | Article |
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By using the Human Intestinal Tract Chip (HITChip) and quantitative PCR of 16S rRNA genes of Bacteria and Archaea, we explored the age-related differences in the gut microbiota composition among young adults, elderly, and centenarians, i.e subjects who reached the extreme limits of the human lifespan, living for over 100 years. We observed that the microbial composition and diversity of the gut ecosystem of young adults and seventy-years old people is highly similar but differs significantly from that of the centenarians. After 100 years of symbiotic association with the human host, the microbiota is characterized by a rearrangement in the Firmicutes population and an enrichment in facultative anaerobes, notably pathobionts. The presence of such a compromised microbiota in the centenarians is associated with an increased inflammatory status, also known as inflammageing, as determined by a range of peripheral blood inflammatory markers. This may be explained by a remodelling of the centenarians' microbiota, with a marked decrease in Faecalibacterium prauznitzii and relatives, symbiotic species with reported anti-inflammatory properties. As signature bacteria of the long life we identified specifically Eubacterium limosum and relatives that were more than ten-fold increased in the centenarians.
We provide evidence for the fact that the ageing process deeply affects the structure of the human gut microbiota, as well as its homeostasis with the host's immune system. Because of its crucial role in the host physiology and health status, age-related differences in the gut microbiota composition may be related to the progression of diseases and frailty in the elderly population.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0010667</identifier><identifier>PMID: 20498852</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Adults ; Age ; Aged ; Aged, 80 and over ; Aging ; Aging - pathology ; Anaerobes ; Anti-inflammatory agents ; Archaea ; Atherosclerosis ; Bacteria ; Bacteroidetes ; butyrate-producing bacteria ; Centenarians ; Cluster Analysis ; Cytokines - blood ; Development and progression ; Diabetes ; Digestive system ; Digestive tract ; Disease susceptibility ; Ecosystems ; Environmental changes ; Epidemiology ; eubacterium-limosum ; fecal microbiota ; Feces ; Feces - microbiology ; Female ; Functional foods & nutraceuticals ; Gastrointestinal system ; Gastrointestinal tract ; Gastrointestinal Tract - microbiology ; Gastrointestinal Tract - pathology ; Geriatrics ; Homeostasis ; human colon ; human feces ; human longevity ; Humans ; Hybridization ; Immune system ; Immunology ; Immunophenotyping ; Inflammation ; Inflammation - microbiology ; Inflammation - pathology ; Insulin resistance ; Intestinal microflora ; Intestine ; Lactobacillus acidophilus ; Life span ; Lymphocyte Subsets - metabolism ; Male ; Metagenome - genetics ; Microbiology ; Microbiology/Environmental Microbiology ; Microbiota ; Microbiota (Symbiotic organisms) ; Microorganisms ; Multivariate analysis ; Older people ; Oldest old people ; Pathology ; Peripheral blood ; Pharmaceutical sciences ; Phylogeny ; Physiological aspects ; Physiology ; Polymerase Chain Reaction ; real-time pcr ; ribosomal-rna gene ; RNA ; rRNA 16S ; t-cells ; Veterinary medicine ; Young Adult ; Young adults</subject><ispartof>PloS one, 2010-05, Vol.5 (5), p.e10667-e10667</ispartof><rights>COPYRIGHT 2010 Public Library of Science</rights><rights>2010 Biagi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Biagi et al. 2010</rights><rights>Wageningen University & Research</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c786t-1a23335bc4b896c9ddcafb59a68d698629559bcca21ff04b3d0c4dad1bdd73aa3</citedby><cites>FETCH-LOGICAL-c786t-1a23335bc4b896c9ddcafb59a68d698629559bcca21ff04b3d0c4dad1bdd73aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871786/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871786/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20498852$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Biagi, E</creatorcontrib><creatorcontrib>Nylund, L</creatorcontrib><creatorcontrib>Candela, M</creatorcontrib><creatorcontrib>Ostan, R</creatorcontrib><creatorcontrib>Bucci, L</creatorcontrib><creatorcontrib>Pini, E</creatorcontrib><creatorcontrib>Nikkïla, J</creatorcontrib><creatorcontrib>Monti, D</creatorcontrib><creatorcontrib>Satokari, R.M</creatorcontrib><creatorcontrib>Franceschi, C</creatorcontrib><creatorcontrib>Brigidi, P</creatorcontrib><creatorcontrib>Vos, W.M. de</creatorcontrib><title>Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Age-related physiological changes in the gastrointestinal tract, as well as modifications in lifestyle, nutritional behaviour, and functionality of the host immune system, inevitably affect the gut microbiota, resulting in a greater susceptibility to infections.
By using the Human Intestinal Tract Chip (HITChip) and quantitative PCR of 16S rRNA genes of Bacteria and Archaea, we explored the age-related differences in the gut microbiota composition among young adults, elderly, and centenarians, i.e subjects who reached the extreme limits of the human lifespan, living for over 100 years. We observed that the microbial composition and diversity of the gut ecosystem of young adults and seventy-years old people is highly similar but differs significantly from that of the centenarians. After 100 years of symbiotic association with the human host, the microbiota is characterized by a rearrangement in the Firmicutes population and an enrichment in facultative anaerobes, notably pathobionts. The presence of such a compromised microbiota in the centenarians is associated with an increased inflammatory status, also known as inflammageing, as determined by a range of peripheral blood inflammatory markers. This may be explained by a remodelling of the centenarians' microbiota, with a marked decrease in Faecalibacterium prauznitzii and relatives, symbiotic species with reported anti-inflammatory properties. As signature bacteria of the long life we identified specifically Eubacterium limosum and relatives that were more than ten-fold increased in the centenarians.
We provide evidence for the fact that the ageing process deeply affects the structure of the human gut microbiota, as well as its homeostasis with the host's immune system. Because of its crucial role in the host physiology and health status, age-related differences in the gut microbiota composition may be related to the progression of diseases and frailty in the elderly population.</description><subject>Adult</subject><subject>Adults</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Aging - pathology</subject><subject>Anaerobes</subject><subject>Anti-inflammatory agents</subject><subject>Archaea</subject><subject>Atherosclerosis</subject><subject>Bacteria</subject><subject>Bacteroidetes</subject><subject>butyrate-producing bacteria</subject><subject>Centenarians</subject><subject>Cluster Analysis</subject><subject>Cytokines - blood</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Digestive system</subject><subject>Digestive tract</subject><subject>Disease susceptibility</subject><subject>Ecosystems</subject><subject>Environmental changes</subject><subject>Epidemiology</subject><subject>eubacterium-limosum</subject><subject>fecal microbiota</subject><subject>Feces</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Functional foods & nutraceuticals</subject><subject>Gastrointestinal system</subject><subject>Gastrointestinal tract</subject><subject>Gastrointestinal Tract - microbiology</subject><subject>Gastrointestinal Tract - pathology</subject><subject>Geriatrics</subject><subject>Homeostasis</subject><subject>human colon</subject><subject>human feces</subject><subject>human longevity</subject><subject>Humans</subject><subject>Hybridization</subject><subject>Immune system</subject><subject>Immunology</subject><subject>Immunophenotyping</subject><subject>Inflammation</subject><subject>Inflammation - microbiology</subject><subject>Inflammation - pathology</subject><subject>Insulin resistance</subject><subject>Intestinal microflora</subject><subject>Intestine</subject><subject>Lactobacillus acidophilus</subject><subject>Life span</subject><subject>Lymphocyte Subsets - metabolism</subject><subject>Male</subject><subject>Metagenome - genetics</subject><subject>Microbiology</subject><subject>Microbiology/Environmental Microbiology</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Microorganisms</subject><subject>Multivariate analysis</subject><subject>Older people</subject><subject>Oldest old people</subject><subject>Pathology</subject><subject>Peripheral blood</subject><subject>Pharmaceutical sciences</subject><subject>Phylogeny</subject><subject>Physiological aspects</subject><subject>Physiology</subject><subject>Polymerase Chain Reaction</subject><subject>real-time pcr</subject><subject>ribosomal-rna gene</subject><subject>RNA</subject><subject>rRNA 16S</subject><subject>t-cells</subject><subject>Veterinary medicine</subject><subject>Young 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(New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>NARCIS:Publications</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Biagi, E</au><au>Nylund, L</au><au>Candela, M</au><au>Ostan, R</au><au>Bucci, L</au><au>Pini, E</au><au>Nikkïla, J</au><au>Monti, D</au><au>Satokari, R.M</au><au>Franceschi, C</au><au>Brigidi, P</au><au>Vos, W.M. de</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2010-05-17</date><risdate>2010</risdate><volume>5</volume><issue>5</issue><spage>e10667</spage><epage>e10667</epage><pages>e10667-e10667</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Age-related physiological changes in the gastrointestinal tract, as well as modifications in lifestyle, nutritional behaviour, and functionality of the host immune system, inevitably affect the gut microbiota, resulting in a greater susceptibility to infections.
By using the Human Intestinal Tract Chip (HITChip) and quantitative PCR of 16S rRNA genes of Bacteria and Archaea, we explored the age-related differences in the gut microbiota composition among young adults, elderly, and centenarians, i.e subjects who reached the extreme limits of the human lifespan, living for over 100 years. We observed that the microbial composition and diversity of the gut ecosystem of young adults and seventy-years old people is highly similar but differs significantly from that of the centenarians. After 100 years of symbiotic association with the human host, the microbiota is characterized by a rearrangement in the Firmicutes population and an enrichment in facultative anaerobes, notably pathobionts. The presence of such a compromised microbiota in the centenarians is associated with an increased inflammatory status, also known as inflammageing, as determined by a range of peripheral blood inflammatory markers. This may be explained by a remodelling of the centenarians' microbiota, with a marked decrease in Faecalibacterium prauznitzii and relatives, symbiotic species with reported anti-inflammatory properties. As signature bacteria of the long life we identified specifically Eubacterium limosum and relatives that were more than ten-fold increased in the centenarians.
We provide evidence for the fact that the ageing process deeply affects the structure of the human gut microbiota, as well as its homeostasis with the host's immune system. Because of its crucial role in the host physiology and health status, age-related differences in the gut microbiota composition may be related to the progression of diseases and frailty in the elderly population.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>20498852</pmid><doi>10.1371/journal.pone.0010667</doi><tpages>e10667</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2010-05, Vol.5 (5), p.e10667-e10667 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1292619220 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Adults Age Aged Aged, 80 and over Aging Aging - pathology Anaerobes Anti-inflammatory agents Archaea Atherosclerosis Bacteria Bacteroidetes butyrate-producing bacteria Centenarians Cluster Analysis Cytokines - blood Development and progression Diabetes Digestive system Digestive tract Disease susceptibility Ecosystems Environmental changes Epidemiology eubacterium-limosum fecal microbiota Feces Feces - microbiology Female Functional foods & nutraceuticals Gastrointestinal system Gastrointestinal tract Gastrointestinal Tract - microbiology Gastrointestinal Tract - pathology Geriatrics Homeostasis human colon human feces human longevity Humans Hybridization Immune system Immunology Immunophenotyping Inflammation Inflammation - microbiology Inflammation - pathology Insulin resistance Intestinal microflora Intestine Lactobacillus acidophilus Life span Lymphocyte Subsets - metabolism Male Metagenome - genetics Microbiology Microbiology/Environmental Microbiology Microbiota Microbiota (Symbiotic organisms) Microorganisms Multivariate analysis Older people Oldest old people Pathology Peripheral blood Pharmaceutical sciences Phylogeny Physiological aspects Physiology Polymerase Chain Reaction real-time pcr ribosomal-rna gene RNA rRNA 16S t-cells Veterinary medicine Young Adult Young adults |
| title | Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians |
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