Alzheimer's disease amyloid-beta links lens and brain pathology in Down syndrome

Down syndrome (DS, trisomy 21) is the most common chromosomal disorder and the leading genetic cause of intellectual disability in humans. In DS, triplication of chromosome 21 invariably includes the APP gene (21q21) encoding the Alzheimer's disease (AD) amyloid precursor protein (APP). Triplic...

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Veröffentlicht in:	PloS one 2010-05, Vol.5 (5), p.e10659-e10659
Hauptverfasser:	Moncaster, Juliet A, Pineda, Roberto, Moir, Robert D, Lu, Suqian, Burton, Mark A, Ghosh, Joy G, Ericsson, Maria, Soscia, Stephanie J, Mocofanescu, Anca, Folkerth, Rebecca D, Robb, Richard M, Kuszak, Jer R, Clark, John I, Tanzi, Rudolph E, Hunter, David G, Goldstein, Lee E
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Adolescent Adult Age Aged Aged, 80 and over Aging Aging - metabolism Aging - pathology Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Alzheimers disease Amino Acid Sequence Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - metabolism Amyloid precursor protein Brain Brain - pathology Brain - ultrastructure Cataract - pathology Cataracts Child Child, Preschool Children & youth Chromosome 21 Cognitive ability Complications Dementia Down syndrome Down Syndrome - metabolism Down Syndrome - pathology Down's syndrome Enzyme-linked immunosorbent assay Enzymes Etiology Eye Proteins - chemistry Eye Proteins - metabolism Female Gene expression Genetics Genotype & phenotype Humans Hypotheses Incubation Intellectual disabilities Laboratories Lens, Crystalline - pathology Lens, Crystalline - ultrastructure Lenses Light Light scattering Male Medical schools Middle Aged Molecular Sequence Data Neurodegenerative diseases Neurological Disorders/Alzheimer Disease Neurological Disorders/Cognitive Neurology and Dementia Neurology Neurosciences Ophthalmology/Cataracts and Other Lens Disorders Pathogenesis Pathology Pathology/Molecular Pathology Peptides Phenotypes Protein interaction Protein Structure, Quaternary Proteins Scattering, Radiation Surgery Trisomy Womens health Young Adult
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