alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population

Insulin resistance is a risk factor for type 2 diabetes and cardiovascular disease progression. Current diagnostic tests, such as glycemic indicators, have limitations in the early detection of insulin resistant individuals. We searched for novel biomarkers identifying these at-risk subjects. Using...

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Veröffentlicht in:	PloS one 2010-05, Vol.5 (5), p.e10883
Hauptverfasser:	Gall, Walter E, Beebe, Kirk, Lawton, Kay A, Adam, Klaus-Peter, Mitchell, Matthew W, Nakhle, Pamela J, Ryals, John A, Milburn, Michael V, Nannipieri, Monica, Camastra, Stefania, Natali, Andrea, Ferrannini, Ele
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino acids Biochemistry Bioindicators Biomarkers Biomarkers - metabolism Biosynthesis Biotechnology Blood glucose Blood Glucose - metabolism Body mass Cardiovascular disease Cardiovascular diseases Chromatography Correlation analysis Demography Diabetes Diabetes and Endocrinology Diabetes and Endocrinology/Obesity Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus - blood Diabetes Mellitus - metabolism Diagnostic systems Dilution Disease control Fatty acids Female Glucose Glucose Intolerance - metabolism Glucose tolerance Health risks Humans Hydroxybutyrates - metabolism Identification methods Insulin Insulin Resistance Intermediates Internal medicine Intolerance Lipid peroxidation Male Mass spectrometry Mass spectroscopy Medicine Metabolism Metabolites Metabolome Middle Aged Models, Biological Oxidation Oxidative stress Pathogenesis Population (statistical) Public Health and Epidemiology/Preventive Medicine Receptor, Insulin - metabolism Resistance factors Risk factors Rodents Scientific imaging Sensitivity Sensitivity analysis Statistical analysis
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