Human rhinovirus infections in rural Thailand: epidemiological evidence for rhinovirus as both pathogen and bystander
We describe human rhinovirus (HRV) detections in SaKaeo province, Thailand. From September 1, 2003-August 31, 2005, we tested hospitalized patients with acute lower respiratory illness and outpatient controls without fever or respiratory symptoms for HRVs with polymerase chain reaction and molecular...
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| Veröffentlicht in: | PloS one 2011-03, Vol.6 (3), p.e17780-e17780 |
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| creator | Fry, Alicia M Lu, Xiaoyan Olsen, Sonja J Chittaganpitch, Malinee Sawatwong, Pongpun Chantra, Somrak Baggett, Henry C Erdman, Dean |
| description | We describe human rhinovirus (HRV) detections in SaKaeo province, Thailand.
From September 1, 2003-August 31, 2005, we tested hospitalized patients with acute lower respiratory illness and outpatient controls without fever or respiratory symptoms for HRVs with polymerase chain reaction and molecularly-typed select HRVs. We compared HRV detection among hospitalized patients and controls and estimated enrollment adjusted incidence.
HRVs were detected in 315 (16%) of 1919 hospitalized patients and 27 (9.6%) of 280 controls. Children had the highest frequency of HRV detections (hospitalized: |
| doi_str_mv | 10.1371/journal.pone.0017780 |
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From September 1, 2003-August 31, 2005, we tested hospitalized patients with acute lower respiratory illness and outpatient controls without fever or respiratory symptoms for HRVs with polymerase chain reaction and molecularly-typed select HRVs. We compared HRV detection among hospitalized patients and controls and estimated enrollment adjusted incidence.
HRVs were detected in 315 (16%) of 1919 hospitalized patients and 27 (9.6%) of 280 controls. Children had the highest frequency of HRV detections (hospitalized: <1 year: 29%, 1-4 year: 29%, ≥ 65 years: 9%; controls: <1 year: 24%, 1-4 year: 14%, ≥ 65 years: 2.8%). Enrollment adjusted hospitalized HRV detection rates were highest among persons aged <1 year (1038/100,000 persons/year), 1-4 years (457), and ≥ 65 years (71). All three HRV species were identified, HRV-A was the most common species in most age groups including children aged <1 year (61%) and all adult age groups. HRV-C was the most common species in the 1-4 year (51%) and 5-19 year age groups (54%). Compared to controls, hospitalized adults (≥ 19 years) and children were more likely to have HRV detections (odds ratio [OR]: 4.8, 95% confidence interval [CI]: 1.5, 15.8; OR: 2.0, CI: 1.2, 3.3, respectively) and hospitalized children were more likely to have HRV-A (OR 1.7, CI: 0.8, 3.5) or HVR-C (OR 2.7, CI: 1.2, 5.9) detection.
HRV rates were high among hospitalized children and the elderly but asymptomatic children also had substantial HRV detection. HRV (all species), and HRV-A and HRV-C detections were epidemiologically-associated with hospitalized illness. Treatment or prevention modalities effective against HRV could reduce hospitalizations due to HRV in Thailand.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0017780</identifier><identifier>PMID: 21479259</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adenoviruses ; Adolescent ; Adult ; Adults ; Age ; Age Distribution ; Aged ; Analysis ; Asthma ; Biology ; Blood ; Bone marrow ; Child ; Child, Preschool ; Children ; Chlamydia ; Chlamydia pneumoniae ; Collaboration ; Confidence intervals ; Disease control ; Enrollments ; Epidemiology ; Fever ; Geriatrics ; Health aspects ; Hospital patients ; Hospitalization ; Hospitals ; Humans ; Illnesses ; Infant ; Infant, Newborn ; Infections ; Influenza ; Influenza, Human - complications ; Influenza, Human - virology ; Legionella ; Medical laboratories ; Medical research ; Medicine ; Middle Aged ; Mycoplasma pneumoniae ; Older people ; Orthomyxoviridae ; Patients ; Picornaviridae Infections - complications ; Picornaviridae Infections - epidemiology ; Picornaviridae Infections - virology ; Pneumonia ; Polymerase chain reaction ; Population ; Respiratory diseases ; Respiratory tract diseases ; Rhinovirus ; Rhinovirus - isolation & purification ; Rhinovirus - physiology ; Rural Population - statistics & numerical data ; Seasons ; Species ; Studies ; Surveillance ; Thailand - epidemiology ; Transplants & implants ; Virology ; Viruses ; Young Adult</subject><ispartof>PloS one, 2011-03, Vol.6 (3), p.e17780-e17780</ispartof><rights>COPYRIGHT 2011 Public Library of Science</rights><rights>2011. This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c757t-6f8bc53f3ee02b4240bd9afcfd417723d3b1875bcbd5b36c0e0b57c90e0d593e3</citedby><cites>FETCH-LOGICAL-c757t-6f8bc53f3ee02b4240bd9afcfd417723d3b1875bcbd5b36c0e0b57c90e0d593e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066183/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066183/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21479259$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fry, Alicia M</creatorcontrib><creatorcontrib>Lu, Xiaoyan</creatorcontrib><creatorcontrib>Olsen, Sonja J</creatorcontrib><creatorcontrib>Chittaganpitch, Malinee</creatorcontrib><creatorcontrib>Sawatwong, Pongpun</creatorcontrib><creatorcontrib>Chantra, Somrak</creatorcontrib><creatorcontrib>Baggett, Henry C</creatorcontrib><creatorcontrib>Erdman, Dean</creatorcontrib><title>Human rhinovirus infections in rural Thailand: epidemiological evidence for rhinovirus as both pathogen and bystander</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>We describe human rhinovirus (HRV) detections in SaKaeo province, Thailand.
From September 1, 2003-August 31, 2005, we tested hospitalized patients with acute lower respiratory illness and outpatient controls without fever or respiratory symptoms for HRVs with polymerase chain reaction and molecularly-typed select HRVs. We compared HRV detection among hospitalized patients and controls and estimated enrollment adjusted incidence.
HRVs were detected in 315 (16%) of 1919 hospitalized patients and 27 (9.6%) of 280 controls. Children had the highest frequency of HRV detections (hospitalized: <1 year: 29%, 1-4 year: 29%, ≥ 65 years: 9%; controls: <1 year: 24%, 1-4 year: 14%, ≥ 65 years: 2.8%). Enrollment adjusted hospitalized HRV detection rates were highest among persons aged <1 year (1038/100,000 persons/year), 1-4 years (457), and ≥ 65 years (71). All three HRV species were identified, HRV-A was the most common species in most age groups including children aged <1 year (61%) and all adult age groups. HRV-C was the most common species in the 1-4 year (51%) and 5-19 year age groups (54%). Compared to controls, hospitalized adults (≥ 19 years) and children were more likely to have HRV detections (odds ratio [OR]: 4.8, 95% confidence interval [CI]: 1.5, 15.8; OR: 2.0, CI: 1.2, 3.3, respectively) and hospitalized children were more likely to have HRV-A (OR 1.7, CI: 0.8, 3.5) or HVR-C (OR 2.7, CI: 1.2, 5.9) detection.
HRV rates were high among hospitalized children and the elderly but asymptomatic children also had substantial HRV detection. HRV (all species), and HRV-A and HRV-C detections were epidemiologically-associated with hospitalized illness. Treatment or prevention modalities effective against HRV could reduce hospitalizations due to HRV in Thailand.</description><subject>Adenoviruses</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Adults</subject><subject>Age</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Analysis</subject><subject>Asthma</subject><subject>Biology</subject><subject>Blood</subject><subject>Bone marrow</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Chlamydia</subject><subject>Chlamydia pneumoniae</subject><subject>Collaboration</subject><subject>Confidence intervals</subject><subject>Disease control</subject><subject>Enrollments</subject><subject>Epidemiology</subject><subject>Fever</subject><subject>Geriatrics</subject><subject>Health aspects</subject><subject>Hospital patients</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infections</subject><subject>Influenza</subject><subject>Influenza, Human - complications</subject><subject>Influenza, Human - virology</subject><subject>Legionella</subject><subject>Medical laboratories</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Mycoplasma pneumoniae</subject><subject>Older people</subject><subject>Orthomyxoviridae</subject><subject>Patients</subject><subject>Picornaviridae Infections - complications</subject><subject>Picornaviridae Infections - epidemiology</subject><subject>Picornaviridae Infections - virology</subject><subject>Pneumonia</subject><subject>Polymerase chain reaction</subject><subject>Population</subject><subject>Respiratory diseases</subject><subject>Respiratory tract diseases</subject><subject>Rhinovirus</subject><subject>Rhinovirus - isolation & purification</subject><subject>Rhinovirus - physiology</subject><subject>Rural Population - statistics & numerical data</subject><subject>Seasons</subject><subject>Species</subject><subject>Studies</subject><subject>Surveillance</subject><subject>Thailand - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fry, Alicia M</au><au>Lu, Xiaoyan</au><au>Olsen, Sonja J</au><au>Chittaganpitch, Malinee</au><au>Sawatwong, Pongpun</au><au>Chantra, Somrak</au><au>Baggett, Henry C</au><au>Erdman, Dean</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human rhinovirus infections in rural Thailand: epidemiological evidence for rhinovirus as both pathogen and bystander</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2011-03-29</date><risdate>2011</risdate><volume>6</volume><issue>3</issue><spage>e17780</spage><epage>e17780</epage><pages>e17780-e17780</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>We describe human rhinovirus (HRV) detections in SaKaeo province, Thailand.
From September 1, 2003-August 31, 2005, we tested hospitalized patients with acute lower respiratory illness and outpatient controls without fever or respiratory symptoms for HRVs with polymerase chain reaction and molecularly-typed select HRVs. We compared HRV detection among hospitalized patients and controls and estimated enrollment adjusted incidence.
HRVs were detected in 315 (16%) of 1919 hospitalized patients and 27 (9.6%) of 280 controls. Children had the highest frequency of HRV detections (hospitalized: <1 year: 29%, 1-4 year: 29%, ≥ 65 years: 9%; controls: <1 year: 24%, 1-4 year: 14%, ≥ 65 years: 2.8%). Enrollment adjusted hospitalized HRV detection rates were highest among persons aged <1 year (1038/100,000 persons/year), 1-4 years (457), and ≥ 65 years (71). All three HRV species were identified, HRV-A was the most common species in most age groups including children aged <1 year (61%) and all adult age groups. HRV-C was the most common species in the 1-4 year (51%) and 5-19 year age groups (54%). Compared to controls, hospitalized adults (≥ 19 years) and children were more likely to have HRV detections (odds ratio [OR]: 4.8, 95% confidence interval [CI]: 1.5, 15.8; OR: 2.0, CI: 1.2, 3.3, respectively) and hospitalized children were more likely to have HRV-A (OR 1.7, CI: 0.8, 3.5) or HVR-C (OR 2.7, CI: 1.2, 5.9) detection.
HRV rates were high among hospitalized children and the elderly but asymptomatic children also had substantial HRV detection. HRV (all species), and HRV-A and HRV-C detections were epidemiologically-associated with hospitalized illness. Treatment or prevention modalities effective against HRV could reduce hospitalizations due to HRV in Thailand.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21479259</pmid><doi>10.1371/journal.pone.0017780</doi><tpages>e17780</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_plos_journals_1292583743 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adenoviruses Adolescent Adult Adults Age Age Distribution Aged Analysis Asthma Biology Blood Bone marrow Child Child, Preschool Children Chlamydia Chlamydia pneumoniae Collaboration Confidence intervals Disease control Enrollments Epidemiology Fever Geriatrics Health aspects Hospital patients Hospitalization Hospitals Humans Illnesses Infant Infant, Newborn Infections Influenza Influenza, Human - complications Influenza, Human - virology Legionella Medical laboratories Medical research Medicine Middle Aged Mycoplasma pneumoniae Older people Orthomyxoviridae Patients Picornaviridae Infections - complications Picornaviridae Infections - epidemiology Picornaviridae Infections - virology Pneumonia Polymerase chain reaction Population Respiratory diseases Respiratory tract diseases Rhinovirus Rhinovirus - isolation & purification Rhinovirus - physiology Rural Population - statistics & numerical data Seasons Species Studies Surveillance Thailand - epidemiology Transplants & implants Virology Viruses Young Adult |
| title | Human rhinovirus infections in rural Thailand: epidemiological evidence for rhinovirus as both pathogen and bystander |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T09%3A29%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Human%20rhinovirus%20infections%20in%20rural%20Thailand:%20epidemiological%20evidence%20for%20rhinovirus%20as%20both%20pathogen%20and%20bystander&rft.jtitle=PloS%20one&rft.au=Fry,%20Alicia%20M&rft.date=2011-03-29&rft.volume=6&rft.issue=3&rft.spage=e17780&rft.epage=e17780&rft.pages=e17780-e17780&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0017780&rft_dat=%3Cgale_plos_%3EA476899404%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1292583743&rft_id=info:pmid/21479259&rft_galeid=A476899404&rft_doaj_id=oai_doaj_org_article_74ae89bd257840cf90f57f7607219f92&rfr_iscdi=true |