Schistosomiasis coinfection in children influences acquired immune response against Plasmodium falciparum malaria antigens
Malaria and schistosomiasis coinfection frequently occurs in tropical countries. This study evaluates the influence of Schistosoma haematobium infection on specific antibody responses and cytokine production to recombinant merozoite surface protein-1-19 (MSP1-(19)) and schizont extract of Plasmodium...
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| Veröffentlicht in: | PloS one 2010-09, Vol.5 (9), p.e12764-e12764 |
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| creator | Diallo, Tamsir O Remoue, Franck Gaayeb, Lobna Schacht, Anne-Marie Charrier, Nicole De Clerck, Dick Dompnier, Jean-Pierre Pillet, Sophie Garraud, Olivier N'Diaye, Abdoulaye A Riveau, Gilles |
| description | Malaria and schistosomiasis coinfection frequently occurs in tropical countries. This study evaluates the influence of Schistosoma haematobium infection on specific antibody responses and cytokine production to recombinant merozoite surface protein-1-19 (MSP1-(19)) and schizont extract of Plasmodium falciparum in malaria-infected children.
Specific IgG1 to MSP1-(19), as well as IgG1 and IgG3 to schizont extract were significantly increased in coinfected children compared to P. falciparum mono-infected children. Stimulation with MSP1-(19) lead to a specific production of both interleukin-10 (IL-10) and interferon-γ (IFN-γ), whereas the stimulation with schizont extract produced an IL-10 response only in the coinfected group.
Our study suggests that schistosomiasis coinfection favours anti-malarial protective antibody responses, which could be associated with the regulation of IL-10 and IFN-γ production and seems to be antigen-dependent. This study demonstrates the importance of infectious status of the population in the evaluation of acquired immunity against malaria and highlights the consequences of a multiple infection environment during clinical trials of anti-malaria vaccine candidates. |
| doi_str_mv | 10.1371/journal.pone.0012764 |
| format | Article |
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Specific IgG1 to MSP1-(19), as well as IgG1 and IgG3 to schizont extract were significantly increased in coinfected children compared to P. falciparum mono-infected children. Stimulation with MSP1-(19) lead to a specific production of both interleukin-10 (IL-10) and interferon-γ (IFN-γ), whereas the stimulation with schizont extract produced an IL-10 response only in the coinfected group.
Our study suggests that schistosomiasis coinfection favours anti-malarial protective antibody responses, which could be associated with the regulation of IL-10 and IFN-γ production and seems to be antigen-dependent. This study demonstrates the importance of infectious status of the population in the evaluation of acquired immunity against malaria and highlights the consequences of a multiple infection environment during clinical trials of anti-malaria vaccine candidates.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0012764</identifier><identifier>PMID: 20856680</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adults ; Age ; Animals ; Antibodies, Helminth - immunology ; Antibodies, Protozoan - immunology ; Antigens ; Antigens, Protozoan - immunology ; Child ; Children ; Clinical trials ; Comorbidity ; Cytokines ; Cytokines - immunology ; Erythrocytes ; Health aspects ; Health care ; Humans ; Immune response ; Immune system ; Immunity ; Immunoglobulin G ; Immunoglobulins ; Immunologic factors ; Immunology/Immune Response ; Immunology/Immunity to Infections ; Infections ; Infectious Diseases ; Interferon ; Interleukin ; Interleukin 10 ; Malaria ; Malaria vaccines ; Malaria, Falciparum - complications ; Malaria, Falciparum - immunology ; Malaria, Falciparum - parasitology ; Male ; Medical research ; Merozoite Surface Protein 1 - immunology ; Parasites ; Plasmodium ; Plasmodium falciparum ; Plasmodium falciparum - immunology ; Plasmodium falciparum - physiology ; Proteins ; Schistosoma ; Schistosoma haematobium ; Schistosoma haematobium - immunology ; Schistosoma haematobium - physiology ; Schistosomiasis ; Schistosomiasis haematobia - complications ; Schistosomiasis haematobia - immunology ; Schistosomiasis haematobia - parasitology ; Stimulation ; Tetanus ; Tropical diseases ; Vaccines ; Vector-borne diseases ; γ-Interferon</subject><ispartof>PloS one, 2010-09, Vol.5 (9), p.e12764-e12764</ispartof><rights>COPYRIGHT 2010 Public Library of Science</rights><rights>2010 Diallo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Diallo et al. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c789t-fabef386030aef99861c49d8b9ae110c2e14a710d01863a53829ebca1f9f4bd53</citedby><cites>FETCH-LOGICAL-c789t-fabef386030aef99861c49d8b9ae110c2e14a710d01863a53829ebca1f9f4bd53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939900/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939900/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20856680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diallo, Tamsir O</creatorcontrib><creatorcontrib>Remoue, Franck</creatorcontrib><creatorcontrib>Gaayeb, Lobna</creatorcontrib><creatorcontrib>Schacht, Anne-Marie</creatorcontrib><creatorcontrib>Charrier, Nicole</creatorcontrib><creatorcontrib>De Clerck, Dick</creatorcontrib><creatorcontrib>Dompnier, Jean-Pierre</creatorcontrib><creatorcontrib>Pillet, Sophie</creatorcontrib><creatorcontrib>Garraud, Olivier</creatorcontrib><creatorcontrib>N'Diaye, Abdoulaye A</creatorcontrib><creatorcontrib>Riveau, Gilles</creatorcontrib><title>Schistosomiasis coinfection in children influences acquired immune response against Plasmodium falciparum malaria antigens</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Malaria and schistosomiasis coinfection frequently occurs in tropical countries. This study evaluates the influence of Schistosoma haematobium infection on specific antibody responses and cytokine production to recombinant merozoite surface protein-1-19 (MSP1-(19)) and schizont extract of Plasmodium falciparum in malaria-infected children.
Specific IgG1 to MSP1-(19), as well as IgG1 and IgG3 to schizont extract were significantly increased in coinfected children compared to P. falciparum mono-infected children. Stimulation with MSP1-(19) lead to a specific production of both interleukin-10 (IL-10) and interferon-γ (IFN-γ), whereas the stimulation with schizont extract produced an IL-10 response only in the coinfected group.
Our study suggests that schistosomiasis coinfection favours anti-malarial protective antibody responses, which could be associated with the regulation of IL-10 and IFN-γ production and seems to be antigen-dependent. 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This study evaluates the influence of Schistosoma haematobium infection on specific antibody responses and cytokine production to recombinant merozoite surface protein-1-19 (MSP1-(19)) and schizont extract of Plasmodium falciparum in malaria-infected children.
Specific IgG1 to MSP1-(19), as well as IgG1 and IgG3 to schizont extract were significantly increased in coinfected children compared to P. falciparum mono-infected children. Stimulation with MSP1-(19) lead to a specific production of both interleukin-10 (IL-10) and interferon-γ (IFN-γ), whereas the stimulation with schizont extract produced an IL-10 response only in the coinfected group.
Our study suggests that schistosomiasis coinfection favours anti-malarial protective antibody responses, which could be associated with the regulation of IL-10 and IFN-γ production and seems to be antigen-dependent. This study demonstrates the importance of infectious status of the population in the evaluation of acquired immunity against malaria and highlights the consequences of a multiple infection environment during clinical trials of anti-malaria vaccine candidates.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>20856680</pmid><doi>10.1371/journal.pone.0012764</doi><tpages>e12764</tpages><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1292534010 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adolescent Adults Age Animals Antibodies, Helminth - immunology Antibodies, Protozoan - immunology Antigens Antigens, Protozoan - immunology Child Children Clinical trials Comorbidity Cytokines Cytokines - immunology Erythrocytes Health aspects Health care Humans Immune response Immune system Immunity Immunoglobulin G Immunoglobulins Immunologic factors Immunology/Immune Response Immunology/Immunity to Infections Infections Infectious Diseases Interferon Interleukin Interleukin 10 Malaria Malaria vaccines Malaria, Falciparum - complications Malaria, Falciparum - immunology Malaria, Falciparum - parasitology Male Medical research Merozoite Surface Protein 1 - immunology Parasites Plasmodium Plasmodium falciparum Plasmodium falciparum - immunology Plasmodium falciparum - physiology Proteins Schistosoma Schistosoma haematobium Schistosoma haematobium - immunology Schistosoma haematobium - physiology Schistosomiasis Schistosomiasis haematobia - complications Schistosomiasis haematobia - immunology Schistosomiasis haematobia - parasitology Stimulation Tetanus Tropical diseases Vaccines Vector-borne diseases γ-Interferon |
| title | Schistosomiasis coinfection in children influences acquired immune response against Plasmodium falciparum malaria antigens |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T09%3A23%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Schistosomiasis%20coinfection%20in%20children%20influences%20acquired%20immune%20response%20against%20Plasmodium%20falciparum%20malaria%20antigens&rft.jtitle=PloS%20one&rft.au=Diallo,%20Tamsir%20O&rft.date=2010-09-15&rft.volume=5&rft.issue=9&rft.spage=e12764&rft.epage=e12764&rft.pages=e12764-e12764&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0012764&rft_dat=%3Cgale_plos_%3EA473859317%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1292534010&rft_id=info:pmid/20856680&rft_galeid=A473859317&rft_doaj_id=oai_doaj_org_article_b4cf1f5d03d044f3adaa16819689c588&rfr_iscdi=true |