Role of Toll-like receptors 2 and 4 in pulmonary inflammation and injury induced by pneumolysin in mice

Pneumolysin (PLN) is an intracellular toxin of Streptococcus pneumoniae that has been implicated as a major virulence factor in infections caused by this pathogen. Conserved bacterial motifs are recognized by the immune system by pattern recognition receptors among which the family of Toll-like rece...

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Veröffentlicht in:	PloS one 2009-11, Vol.4 (11), p.e7993-e7993
Hauptverfasser:	Dessing, Mark C, Hirst, Robert A, de Vos, Alex F, van der Poll, Tom
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Animals Bacteria Bacterial Proteins - metabolism Bronchoalveolar Lavage Fluid Bronchus Chemokines Cytokines Data processing Drug dosages E coli Escherichia coli Experiments Gene expression Health aspects Humans Immune system Immunology/Immunity to Infections Immunology/Innate Immunity Infection Infectious Diseases/Bacterial Infections Inflammation Inflammatory response Injuries Intranasal administration Kidney - metabolism Leukocytes (neutrophilic) Ligands Lung Lung - immunology Lung - microbiology Lungs Mice Mice, Inbred C57BL Mice, Knockout Pathogens Pattern recognition Pattern recognition receptors Pneumolysin Pneumonia Proteins Receptors Staphylococcus aureus Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - metabolism Streptolysins - metabolism Tetrazolium Salts - pharmacology Thiazoles - pharmacology TLR2 protein TLR4 protein Toll-Like Receptor 2 - metabolism Toll-Like Receptor 4 - metabolism Toll-like receptors Tolls Toxins Virulence Virulence (Microbiology) Virulence Factors
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