Differential deployment of REST and CoREST promotes glial subtype specification and oligodendrocyte lineage maturation

The repressor element-1 (RE1) silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) is a master transcriptional regulator that binds to numerous genomic RE1 sites where it acts as a molecular scaffold for dynamic recruitment of modulatory and epigenetic cofactors, including c...

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Veröffentlicht in:	PloS one 2009-11, Vol.4 (11), p.e7665-e7665
Hauptverfasser:	Abrajano, Joseph J, Qureshi, Irfan A, Gokhan, Solen, Zheng, Deyou, Bergman, Aviv, Mehler, Mark F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Artificial neural networks Astrocytes - metabolism Brain - embryology Cell Differentiation Cell Lineage Cofactors Combinatorial analysis Coupling (molecular) Developmental stages Differentiation Epigenesis, Genetic Epigenetic inheritance Gene regulation Gene Silencing Genes Glial cells Glial plasticity Gliogenesis Homeostasis Kinases Macromolecules Maturation Mice Migraine Myelination Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - physiology Nervous system diseases Neural networks Neural plasticity Neural stem cells Neurogenesis Neuroglia - cytology Neurological Disorders/Neurogenetics Neuronal-glial interactions Neurons Neurons - metabolism Neuroplasticity Neuroscience/Neurobiology of Disease and Regeneration Neuroscience/Neurodevelopment Neuroscience/Neuronal and Glial Cell Biology Oligodendroglia - cytology Oligonucleotide Array Sequence Analysis Regulatory sequences Repressor Proteins - biosynthesis Repressor Proteins - physiology Rest REST protein Rodents Signaling Specifications Stem cells Synaptic plasticity Transcription (Genetics) Transcription Factors - metabolism
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