Differential deployment of REST and CoREST promotes glial subtype specification and oligodendrocyte lineage maturation
The repressor element-1 (RE1) silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) is a master transcriptional regulator that binds to numerous genomic RE1 sites where it acts as a molecular scaffold for dynamic recruitment of modulatory and epigenetic cofactors, including c...
Gespeichert in:
| Veröffentlicht in: | PloS one 2009-11, Vol.4 (11), p.e7665-e7665 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e7665 |
|---|---|
| container_issue | 11 |
| container_start_page | e7665 |
| container_title | PloS one |
| container_volume | 4 |
| creator | Abrajano, Joseph J Qureshi, Irfan A Gokhan, Solen Zheng, Deyou Bergman, Aviv Mehler, Mark F |
| description | The repressor element-1 (RE1) silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) is a master transcriptional regulator that binds to numerous genomic RE1 sites where it acts as a molecular scaffold for dynamic recruitment of modulatory and epigenetic cofactors, including corepressor for element-1-silencing transcription factor (CoREST). CoREST also acts as a hub for various cofactors that play important roles in epigenetic remodeling and transcriptional regulation. While REST can recruit CoREST to its macromolecular complex, CoREST complexes also function at genomic sites independently of REST. REST and CoREST perform a broad array of context-specific functions, which include repression of neuronal differentiation genes in neural stem cells (NSCs) and other non-neuronal cells as well as promotion of neurogenesis. Despite their involvement in multiple aspects of neuronal development, REST and CoREST are not believed to have any direct modulatory roles in glial cell maturation.
We challenged this view by performing the first study of REST and CoREST in NSC-mediated glial lineage specification and differentiation. Utilizing ChIP on chip (ChIP-chip) assays, we identified distinct but overlapping developmental stage-specific profiles for REST and CoREST target genes during astrocyte (AS) and oligodendrocyte (OL) lineage specification and OL lineage maturation and myelination, including many genes not previously implicated in glial cell biology or linked to REST and CoREST regulation. Amongst these factors are those implicated in macroglial (AS and OL) cell identity, maturation, and maintenance, such as members of key developmental signaling pathways and combinatorial transcription factor codes.
Our results imply that REST and CoREST modulate not only neuronal but also glial lineage elaboration. These factors may therefore mediate critical developmental processes including the coupling of neurogenesis and gliogenesis and neuronal-glial interactions that underlie synaptic and neural network plasticity and homeostasis in health and in specific neurological disease states. |
| doi_str_mv | 10.1371/journal.pone.0007665 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1292493706</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A472814355</galeid><doaj_id>oai_doaj_org_article_710d23f6b06d407198d4045772e1b1f1</doaj_id><sourcerecordid>A472814355</sourcerecordid><originalsourceid>FETCH-LOGICAL-c729t-e86921b39223ba8033afe393b5105dc836f662202356cd79cbfad509e3e496bd3</originalsourceid><addsrcrecordid>eNqNkl9v0zAUxSMEYmPwDRBEQgLx0OI_iZO8IE1lQKVJk7bBq-XY16knJ-5sZ6LfHrcN0CIeUB7sOL97bu7xybKXGM0xrfCHOzf6Qdj52g0wRwhVjJWPslPcUDJjBNHHB_uT7FkIdwiVtGbsaXaCm7quaUFOs4dPRmvwMEQjbK5gbd2mT2-50_n1xc1tLgaVL9xuu_audxFC3tktHMY2btaQhzVIo40U0bhhxztrOqdgUN7JTYTcmgFEB3kv4uh32PPsiRY2wItpPcu-fb64XXydXV59WS7OL2eyIk2cQc0aglvaEEJbUSNKhQba0LbEqFSypkwzRggitGRSVY1stVAlaoBC0bBW0bPs9V43zRX4ZFngmDSkaGiFWCKWe0I5ccfX3vTCb7gThu8OnO-48NFIC7zCSBGqWYuYKlCVTExLUVYVAdxijZPWx6nb2PagZPLRC3skevxlMCveuQdO0uUhipLAu0nAu_sRQuS9CRKsFQO4MfCK0nRzpN62evMX-e_h5nuqE-n_zaBdaivTo6A3MgVHm3R-XlRJsqBlmQreHxUkJsKP2IkxBL68uf5_9ur7Mfv2gF2BsHEVnB23WQjHYLEHpXcheNC_3cOIb3P_a06-zT2fcp_KXh06_6doCjr9CeA5_tA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1292493706</pqid></control><display><type>article</type><title>Differential deployment of REST and CoREST promotes glial subtype specification and oligodendrocyte lineage maturation</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Abrajano, Joseph J ; Qureshi, Irfan A ; Gokhan, Solen ; Zheng, Deyou ; Bergman, Aviv ; Mehler, Mark F</creator><contributor>Linden, Rafael</contributor><creatorcontrib>Abrajano, Joseph J ; Qureshi, Irfan A ; Gokhan, Solen ; Zheng, Deyou ; Bergman, Aviv ; Mehler, Mark F ; Linden, Rafael</creatorcontrib><description>The repressor element-1 (RE1) silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) is a master transcriptional regulator that binds to numerous genomic RE1 sites where it acts as a molecular scaffold for dynamic recruitment of modulatory and epigenetic cofactors, including corepressor for element-1-silencing transcription factor (CoREST). CoREST also acts as a hub for various cofactors that play important roles in epigenetic remodeling and transcriptional regulation. While REST can recruit CoREST to its macromolecular complex, CoREST complexes also function at genomic sites independently of REST. REST and CoREST perform a broad array of context-specific functions, which include repression of neuronal differentiation genes in neural stem cells (NSCs) and other non-neuronal cells as well as promotion of neurogenesis. Despite their involvement in multiple aspects of neuronal development, REST and CoREST are not believed to have any direct modulatory roles in glial cell maturation.
We challenged this view by performing the first study of REST and CoREST in NSC-mediated glial lineage specification and differentiation. Utilizing ChIP on chip (ChIP-chip) assays, we identified distinct but overlapping developmental stage-specific profiles for REST and CoREST target genes during astrocyte (AS) and oligodendrocyte (OL) lineage specification and OL lineage maturation and myelination, including many genes not previously implicated in glial cell biology or linked to REST and CoREST regulation. Amongst these factors are those implicated in macroglial (AS and OL) cell identity, maturation, and maintenance, such as members of key developmental signaling pathways and combinatorial transcription factor codes.
Our results imply that REST and CoREST modulate not only neuronal but also glial lineage elaboration. These factors may therefore mediate critical developmental processes including the coupling of neurogenesis and gliogenesis and neuronal-glial interactions that underlie synaptic and neural network plasticity and homeostasis in health and in specific neurological disease states.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0007665</identifier><identifier>PMID: 19888342</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Artificial neural networks ; Astrocytes - metabolism ; Brain - embryology ; Cell Differentiation ; Cell Lineage ; Cofactors ; Combinatorial analysis ; Coupling (molecular) ; Developmental stages ; Differentiation ; Epigenesis, Genetic ; Epigenetic inheritance ; Gene regulation ; Gene Silencing ; Genes ; Glial cells ; Glial plasticity ; Gliogenesis ; Homeostasis ; Kinases ; Macromolecules ; Maturation ; Mice ; Migraine ; Myelination ; Nerve Tissue Proteins - biosynthesis ; Nerve Tissue Proteins - physiology ; Nervous system diseases ; Neural networks ; Neural plasticity ; Neural stem cells ; Neurogenesis ; Neuroglia - cytology ; Neurological Disorders/Neurogenetics ; Neuronal-glial interactions ; Neurons ; Neurons - metabolism ; Neuroplasticity ; Neuroscience/Neurobiology of Disease and Regeneration ; Neuroscience/Neurodevelopment ; Neuroscience/Neuronal and Glial Cell Biology ; Oligodendroglia - cytology ; Oligonucleotide Array Sequence Analysis ; Regulatory sequences ; Repressor Proteins - biosynthesis ; Repressor Proteins - physiology ; Rest ; REST protein ; Rodents ; Signaling ; Specifications ; Stem cells ; Synaptic plasticity ; Transcription (Genetics) ; Transcription Factors - metabolism</subject><ispartof>PloS one, 2009-11, Vol.4 (11), p.e7665-e7665</ispartof><rights>COPYRIGHT 2009 Public Library of Science</rights><rights>2009 Abrajano et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Abrajano et al. 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c729t-e86921b39223ba8033afe393b5105dc836f662202356cd79cbfad509e3e496bd3</citedby><cites>FETCH-LOGICAL-c729t-e86921b39223ba8033afe393b5105dc836f662202356cd79cbfad509e3e496bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766030/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766030/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19888342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Linden, Rafael</contributor><creatorcontrib>Abrajano, Joseph J</creatorcontrib><creatorcontrib>Qureshi, Irfan A</creatorcontrib><creatorcontrib>Gokhan, Solen</creatorcontrib><creatorcontrib>Zheng, Deyou</creatorcontrib><creatorcontrib>Bergman, Aviv</creatorcontrib><creatorcontrib>Mehler, Mark F</creatorcontrib><title>Differential deployment of REST and CoREST promotes glial subtype specification and oligodendrocyte lineage maturation</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The repressor element-1 (RE1) silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) is a master transcriptional regulator that binds to numerous genomic RE1 sites where it acts as a molecular scaffold for dynamic recruitment of modulatory and epigenetic cofactors, including corepressor for element-1-silencing transcription factor (CoREST). CoREST also acts as a hub for various cofactors that play important roles in epigenetic remodeling and transcriptional regulation. While REST can recruit CoREST to its macromolecular complex, CoREST complexes also function at genomic sites independently of REST. REST and CoREST perform a broad array of context-specific functions, which include repression of neuronal differentiation genes in neural stem cells (NSCs) and other non-neuronal cells as well as promotion of neurogenesis. Despite their involvement in multiple aspects of neuronal development, REST and CoREST are not believed to have any direct modulatory roles in glial cell maturation.
We challenged this view by performing the first study of REST and CoREST in NSC-mediated glial lineage specification and differentiation. Utilizing ChIP on chip (ChIP-chip) assays, we identified distinct but overlapping developmental stage-specific profiles for REST and CoREST target genes during astrocyte (AS) and oligodendrocyte (OL) lineage specification and OL lineage maturation and myelination, including many genes not previously implicated in glial cell biology or linked to REST and CoREST regulation. Amongst these factors are those implicated in macroglial (AS and OL) cell identity, maturation, and maintenance, such as members of key developmental signaling pathways and combinatorial transcription factor codes.
Our results imply that REST and CoREST modulate not only neuronal but also glial lineage elaboration. These factors may therefore mediate critical developmental processes including the coupling of neurogenesis and gliogenesis and neuronal-glial interactions that underlie synaptic and neural network plasticity and homeostasis in health and in specific neurological disease states.</description><subject>Animals</subject><subject>Artificial neural networks</subject><subject>Astrocytes - metabolism</subject><subject>Brain - embryology</subject><subject>Cell Differentiation</subject><subject>Cell Lineage</subject><subject>Cofactors</subject><subject>Combinatorial analysis</subject><subject>Coupling (molecular)</subject><subject>Developmental stages</subject><subject>Differentiation</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetic inheritance</subject><subject>Gene regulation</subject><subject>Gene Silencing</subject><subject>Genes</subject><subject>Glial cells</subject><subject>Glial plasticity</subject><subject>Gliogenesis</subject><subject>Homeostasis</subject><subject>Kinases</subject><subject>Macromolecules</subject><subject>Maturation</subject><subject>Mice</subject><subject>Migraine</subject><subject>Myelination</subject><subject>Nerve Tissue Proteins - biosynthesis</subject><subject>Nerve Tissue Proteins - physiology</subject><subject>Nervous system diseases</subject><subject>Neural networks</subject><subject>Neural plasticity</subject><subject>Neural stem cells</subject><subject>Neurogenesis</subject><subject>Neuroglia - cytology</subject><subject>Neurological Disorders/Neurogenetics</subject><subject>Neuronal-glial interactions</subject><subject>Neurons</subject><subject>Neurons - metabolism</subject><subject>Neuroplasticity</subject><subject>Neuroscience/Neurobiology of Disease and Regeneration</subject><subject>Neuroscience/Neurodevelopment</subject><subject>Neuroscience/Neuronal and Glial Cell Biology</subject><subject>Oligodendroglia - cytology</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Regulatory sequences</subject><subject>Repressor Proteins - biosynthesis</subject><subject>Repressor Proteins - physiology</subject><subject>Rest</subject><subject>REST protein</subject><subject>Rodents</subject><subject>Signaling</subject><subject>Specifications</subject><subject>Stem cells</subject><subject>Synaptic plasticity</subject><subject>Transcription (Genetics)</subject><subject>Transcription Factors - metabolism</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl9v0zAUxSMEYmPwDRBEQgLx0OI_iZO8IE1lQKVJk7bBq-XY16knJ-5sZ6LfHrcN0CIeUB7sOL97bu7xybKXGM0xrfCHOzf6Qdj52g0wRwhVjJWPslPcUDJjBNHHB_uT7FkIdwiVtGbsaXaCm7quaUFOs4dPRmvwMEQjbK5gbd2mT2-50_n1xc1tLgaVL9xuu_audxFC3tktHMY2btaQhzVIo40U0bhhxztrOqdgUN7JTYTcmgFEB3kv4uh32PPsiRY2wItpPcu-fb64XXydXV59WS7OL2eyIk2cQc0aglvaEEJbUSNKhQba0LbEqFSypkwzRggitGRSVY1stVAlaoBC0bBW0bPs9V43zRX4ZFngmDSkaGiFWCKWe0I5ccfX3vTCb7gThu8OnO-48NFIC7zCSBGqWYuYKlCVTExLUVYVAdxijZPWx6nb2PagZPLRC3skevxlMCveuQdO0uUhipLAu0nAu_sRQuS9CRKsFQO4MfCK0nRzpN62evMX-e_h5nuqE-n_zaBdaivTo6A3MgVHm3R-XlRJsqBlmQreHxUkJsKP2IkxBL68uf5_9ur7Mfv2gF2BsHEVnB23WQjHYLEHpXcheNC_3cOIb3P_a06-zT2fcp_KXh06_6doCjr9CeA5_tA</recordid><startdate>20091103</startdate><enddate>20091103</enddate><creator>Abrajano, Joseph J</creator><creator>Qureshi, Irfan A</creator><creator>Gokhan, Solen</creator><creator>Zheng, Deyou</creator><creator>Bergman, Aviv</creator><creator>Mehler, Mark F</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20091103</creationdate><title>Differential deployment of REST and CoREST promotes glial subtype specification and oligodendrocyte lineage maturation</title><author>Abrajano, Joseph J ; Qureshi, Irfan A ; Gokhan, Solen ; Zheng, Deyou ; Bergman, Aviv ; Mehler, Mark F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c729t-e86921b39223ba8033afe393b5105dc836f662202356cd79cbfad509e3e496bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Artificial neural networks</topic><topic>Astrocytes - metabolism</topic><topic>Brain - embryology</topic><topic>Cell Differentiation</topic><topic>Cell Lineage</topic><topic>Cofactors</topic><topic>Combinatorial analysis</topic><topic>Coupling (molecular)</topic><topic>Developmental stages</topic><topic>Differentiation</topic><topic>Epigenesis, Genetic</topic><topic>Epigenetic inheritance</topic><topic>Gene regulation</topic><topic>Gene Silencing</topic><topic>Genes</topic><topic>Glial cells</topic><topic>Glial plasticity</topic><topic>Gliogenesis</topic><topic>Homeostasis</topic><topic>Kinases</topic><topic>Macromolecules</topic><topic>Maturation</topic><topic>Mice</topic><topic>Migraine</topic><topic>Myelination</topic><topic>Nerve Tissue Proteins - biosynthesis</topic><topic>Nerve Tissue Proteins - physiology</topic><topic>Nervous system diseases</topic><topic>Neural networks</topic><topic>Neural plasticity</topic><topic>Neural stem cells</topic><topic>Neurogenesis</topic><topic>Neuroglia - cytology</topic><topic>Neurological Disorders/Neurogenetics</topic><topic>Neuronal-glial interactions</topic><topic>Neurons</topic><topic>Neurons - metabolism</topic><topic>Neuroplasticity</topic><topic>Neuroscience/Neurobiology of Disease and Regeneration</topic><topic>Neuroscience/Neurodevelopment</topic><topic>Neuroscience/Neuronal and Glial Cell Biology</topic><topic>Oligodendroglia - cytology</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Regulatory sequences</topic><topic>Repressor Proteins - biosynthesis</topic><topic>Repressor Proteins - physiology</topic><topic>Rest</topic><topic>REST protein</topic><topic>Rodents</topic><topic>Signaling</topic><topic>Specifications</topic><topic>Stem cells</topic><topic>Synaptic plasticity</topic><topic>Transcription (Genetics)</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abrajano, Joseph J</creatorcontrib><creatorcontrib>Qureshi, Irfan A</creatorcontrib><creatorcontrib>Gokhan, Solen</creatorcontrib><creatorcontrib>Zheng, Deyou</creatorcontrib><creatorcontrib>Bergman, Aviv</creatorcontrib><creatorcontrib>Mehler, Mark F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abrajano, Joseph J</au><au>Qureshi, Irfan A</au><au>Gokhan, Solen</au><au>Zheng, Deyou</au><au>Bergman, Aviv</au><au>Mehler, Mark F</au><au>Linden, Rafael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential deployment of REST and CoREST promotes glial subtype specification and oligodendrocyte lineage maturation</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2009-11-03</date><risdate>2009</risdate><volume>4</volume><issue>11</issue><spage>e7665</spage><epage>e7665</epage><pages>e7665-e7665</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The repressor element-1 (RE1) silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) is a master transcriptional regulator that binds to numerous genomic RE1 sites where it acts as a molecular scaffold for dynamic recruitment of modulatory and epigenetic cofactors, including corepressor for element-1-silencing transcription factor (CoREST). CoREST also acts as a hub for various cofactors that play important roles in epigenetic remodeling and transcriptional regulation. While REST can recruit CoREST to its macromolecular complex, CoREST complexes also function at genomic sites independently of REST. REST and CoREST perform a broad array of context-specific functions, which include repression of neuronal differentiation genes in neural stem cells (NSCs) and other non-neuronal cells as well as promotion of neurogenesis. Despite their involvement in multiple aspects of neuronal development, REST and CoREST are not believed to have any direct modulatory roles in glial cell maturation.
We challenged this view by performing the first study of REST and CoREST in NSC-mediated glial lineage specification and differentiation. Utilizing ChIP on chip (ChIP-chip) assays, we identified distinct but overlapping developmental stage-specific profiles for REST and CoREST target genes during astrocyte (AS) and oligodendrocyte (OL) lineage specification and OL lineage maturation and myelination, including many genes not previously implicated in glial cell biology or linked to REST and CoREST regulation. Amongst these factors are those implicated in macroglial (AS and OL) cell identity, maturation, and maintenance, such as members of key developmental signaling pathways and combinatorial transcription factor codes.
Our results imply that REST and CoREST modulate not only neuronal but also glial lineage elaboration. These factors may therefore mediate critical developmental processes including the coupling of neurogenesis and gliogenesis and neuronal-glial interactions that underlie synaptic and neural network plasticity and homeostasis in health and in specific neurological disease states.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>19888342</pmid><doi>10.1371/journal.pone.0007665</doi><tpages>e7665</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2009-11, Vol.4 (11), p.e7665-e7665 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1292493706 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Artificial neural networks Astrocytes - metabolism Brain - embryology Cell Differentiation Cell Lineage Cofactors Combinatorial analysis Coupling (molecular) Developmental stages Differentiation Epigenesis, Genetic Epigenetic inheritance Gene regulation Gene Silencing Genes Glial cells Glial plasticity Gliogenesis Homeostasis Kinases Macromolecules Maturation Mice Migraine Myelination Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - physiology Nervous system diseases Neural networks Neural plasticity Neural stem cells Neurogenesis Neuroglia - cytology Neurological Disorders/Neurogenetics Neuronal-glial interactions Neurons Neurons - metabolism Neuroplasticity Neuroscience/Neurobiology of Disease and Regeneration Neuroscience/Neurodevelopment Neuroscience/Neuronal and Glial Cell Biology Oligodendroglia - cytology Oligonucleotide Array Sequence Analysis Regulatory sequences Repressor Proteins - biosynthesis Repressor Proteins - physiology Rest REST protein Rodents Signaling Specifications Stem cells Synaptic plasticity Transcription (Genetics) Transcription Factors - metabolism |
| title | Differential deployment of REST and CoREST promotes glial subtype specification and oligodendrocyte lineage maturation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T21%3A58%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Differential%20deployment%20of%20REST%20and%20CoREST%20promotes%20glial%20subtype%20specification%20and%20oligodendrocyte%20lineage%20maturation&rft.jtitle=PloS%20one&rft.au=Abrajano,%20Joseph%20J&rft.date=2009-11-03&rft.volume=4&rft.issue=11&rft.spage=e7665&rft.epage=e7665&rft.pages=e7665-e7665&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0007665&rft_dat=%3Cgale_plos_%3EA472814355%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1292493706&rft_id=info:pmid/19888342&rft_galeid=A472814355&rft_doaj_id=oai_doaj_org_article_710d23f6b06d407198d4045772e1b1f1&rfr_iscdi=true |